ArticleTherapeutic advances in medical oncology2025
Interim C-reactive protein levels predict the prognosis of patients with metastatic colorectal cancer receiving immunotherapy: a retrospective cohort study.
Article in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Prognostic Factors and Biomarker Performance in Patients with Colorectal Cancer Receiving Reduced-Dose 5-Fluorouracil Therapy: A Retrospective Cohort Analysis.Journal of clinical medicine · 2025Article
- Prognostic Significance of baseline systemic inflammation markers in PD-L1-negative advanced non-small cell lung cancer patients treated with the BRICS sequential regimen.Frontiers in immunology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: Serum C-reactive protein (CRP) level is frequently considered a prognostic predictor of immunotherapy. However, the prognostic role of the interim serum CRP levels before the third course of immunotherapy (CRP-C3) in patients with metastatic colorectal cancer (mCRC) receiving immunotherapy remains unclear. Objectives: This study aimed to determine the predictive value of CRP-C3 for immunotherapy response and progression-free survival (PFS) and to compare its performance with other biomarkers, such as tumor mutational burden (TMB). Design: We conducted a retrospective cohort study of 205 patients with mCRC who received immunotherapy. Methods: Baseline CRP (CRP-B) and CRP-C3 levels were measured in this retrospective cohort study. Clinicopathological data were retrospectively analyzed using Cox regression analyses to identify independent predictive variables for immunotherapy response and PFS, then summarized in nomograms to predict prognosis. Results: The median PFS periods were 8.47 months in the CRP-C3-low subgroup and 2.47 months in the CRP-C3-high subgroup ( Conclusion: This retrospective study indicates a potential association between decreased CRP-C3 levels and improved PFS in patients with mCRC receiving immunotherapy. The combination of CRP-C3 and TMB appeared to enhance predictive performance, suggesting their possible utility as prognostic indicators.
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