ArticleJournal of environmental health science & engineering2025
Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis.
Article in Journal of environmental health science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Multi-Dimensional Perspective of the Gene and Environmental Interaction in Asthma.Clinical reviews in allergy & immunology · 2026Review
- Plastic Pollution and Child Health: A Narrative Review of Micro- and Nanoplastics, Additives, and Developmental Risks.Journal of clinical medicine · 2025Review
- Associations Between Prenatal Phthalate Exposure and Atopic Symptoms in Childhood: Effect Modification by Child Sex.Toxics · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Phthalates are one of the most common environmental contaminants and endocrine disruptors. Environmental exposure to phthalates may increase the risk for allergic diseases. However, the existing literature presents conflicting findings regarding the long-term impact of early-life exposure to these substances. Methods: We searched the Web of Science, PubMed and Google Scholar, Medline and Embase databases for all related publications from 1974 to September 1st, 2024. Ultimately, 22 studies with a total of 16,161 participants were selected. The relative risks (RRs) with 95% confidence intervals (95% CIs) were used to evaluate whether prenatal phthalate exposure is associated with allergic endpoints. To assess statistical heterogeneity across studies, both the Q-test and Results: Childhood wheeze (RR 1.10, 95% CI: 1.00-1.21), eczema (RR 1.09, 95% CI: 1.01-1.17), and rhinitis (RR 1.05, 95% CI: 1.02-1.09) are potentially associated with prenatal exposure to phthalates, particularly butyl-benzyl phthalate (RR 1.15, 95% CI: 1.06-1.24), di-ethyl-hexyl phthalate (RR 1.08, 95% CI: 1.02-1.15) and di-iso-nonyl phthalate (RR 1.12, 95% CI: 1.02-1.23). Conclusion: Maternal phthalate exposure during pregnancy exhibits a significant association with elevated risks of childhood respiratory and allergic manifestations, including wheezing episodes, eczematous dermatitis, and rhinitis symptoms. Supplementary Information: The online version contains supplementary material available at 10.1007/s40201-025-00951-3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.