Evidence map›Paper›PMID 40762246›Full record

ArticleGlia2025

Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage.

Okan Capuk, Elise Berthold, Kathiravan Kaliyappan, Mansi Avunoori, Rajesh Muduganti, Sanjana Krishna, Shamseldin Metwally, Mary McFarland, Shanshan Song, Victoria Fiesler and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Okan CapukDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1544-6756
Elise BertholdDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kathiravan KaliyappanDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mansi AvunooriDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Rajesh MudugantiDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sanjana KrishnaCarnegie Mellon University, Department of Biological Sciences, Pittsburgh, Pennsylvania, USA.
Shamseldin MetwallyDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3819-6665
Mary McFarlandDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Shanshan SongDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Victoria FieslerDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sydney FischerDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lesley M FoleyAdvanced Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
T Kevin HitchensAdvanced Imaging Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Susannah WaxmanDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ian A SigalDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Shefeeq M TheparambilDepartment of Biomedical and Life Sciences, Lancaster University, Lancaster, UK.
Gulnaz BegumDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1509-0630

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI John D Ash · 1989 to 2026
$17.8M
Astrocytic NBCe1 in regulation of blood brain barrier integrityR21NS131754 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BEGUM, GULNAZ · 2023 to 2023
$428k
NEI NIH HHS P30 EY008098NIH HHS P30-EY008098NIH HHS R21 NS131754-01A1NINDS NIH HHS R21 NS131754Royal Society RGS/R2/242117
6 · The paper itself

Abstract

The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in astrocytes, is important for brain pH regulation and homeostasis. Increased NBCe1 expression in reactive astrocytes has been associated with neuronal degeneration in ischemic stroke. However, the effects of astrocytic NBCe1 inhibition in stroke remain contradictory, and the underlying mechanisms are unclear. Here, we show that wild-type (WT) mice exhibited elevated NBCe1 expression in the peri-lesional regions at 3 days post-stroke. Astrocytic Nbce1 gene deletion in inducible Gfap-Cre

Indexed as

AstrocytesIschemic StrokeSodium-Bicarbonate SymportersAnimalsBlood-Brain BarrierGene DeletionMaleMiceMice, Inbred C57BLMice, TransgenicSlc4a4 protein, mouseSodium-Bicarbonate SymportersAQP4astrocytic end‐feetbrain pH homeostasisischemic strokeNBCe1

Identifiers

PMID40762246
PMCPMC12541896

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.