ArticleInvestigative ophthalmology & visual science2025
Exploring the Therapeutic Potential of Salivary Exosomes in Corneal Epithelial Wound Healing.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- The Therapeutic Potential of Exosomes in Ocular Surface Diseases.Biomolecules · 2026Review
- Endogenous Therapeutic Agents for Acute Corneal and Ocular Surface Injuries.Translational vision science & technology · 2026Review
- Ferroptosis: A Novel Mechanism in Diabetic Keratopathy.Investigative ophthalmology & visual science · 2026Article
- Corneal Extracellular Vesicles: Small Packages with a Big Impact.Pharmaceutics · 2026Review
- Harnessing the Therapeutic Potential of Extracellular Vesicles for Oral Wound Healing.Bioengineering (Basel, Switzerland) · 2026Review
- Exosomes in corneal diseases: advances in diagnosis and therapy.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Purpose: This study aimed to evaluate the therapeutic potential of salivary exosomes (SEs) in corneal epithelial wound healing by assessing their effects on wound closure, cellular function, and molecular mechanisms in both in vivo and in vitro models. Methods: Corneal epithelial wounds were induced in C57BL/6J mice and treated with topical SEs (10 µg/eye) twice daily. Wound closure was monitored using fluorescein staining. In vitro, primary human corneal epithelial cells (HCECs) and human limbal epithelial cells (HLECs) were treated with SEs (0, 5, and 25 µg/mL) to assess migration, proliferation, and mitochondrial function. Western blot and immunohistochemistry were used to evaluate key molecular markers, including integrin α6, integrin β4, thrombospondin-1 (TSP1), and transforming growth factor-β1 (TGF-β1). Results: SE treatment significantly accelerated corneal wound closure in vivo. In vitro, SEs enhanced HCEC and HLEC migration, proliferation, and mitochondrial function. SEs upregulated integrin α6, integrin β4, and TSP1 expression in both wounded corneas and cultured HCECs. TGF-β1 levels were transiently increased in exosome-treated corneas but returned to baseline as healing progressed. Mitochondrial stress assays revealed that SEs enhanced oxidative phosphorylation in HCECs and HLECs. Conclusions: SEs promote corneal epithelial wound healing by enhancing cellular migration, proliferation, and mitochondrial function while modulating key molecular pathways. These findings suggest that SEs represent a novel therapeutic strategy for corneal injury, warranting further investigation into their mechanisms and clinical applications.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.