Evidence map›Paper›PMID 40762575›Full record

ArticleDevelopment (Cambridge, England)2025

KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration.

Yitong Liu, Wentong Hong, Yuyan Zhou, Ailing Zhang, Pifang Gong, Guibo Qi, Xuan Song, Zhenru Wang, Xuanming Shi, Congcong Qi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yitong LiuDepartment of Neurology, Shanghai Pudong Hospital and Department of Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Wentong HongDepartment of Anatomy, School of Basic Medical Sciences, Bengbu Medical University, Bengbu, 233030, China.
Yuyan ZhouDepartment of Neurology, Shanghai Pudong Hospital and Department of Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Ailing ZhangDepartment of Biochemistry, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.
Pifang GongDepartment of Neurology, Shanghai Pudong Hospital and Department of Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Guibo QiDepartment of Neurology, Shanghai Pudong Hospital and Department of Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Xuan SongDepartment of Neurology, Shanghai Pudong Hospital and Department of Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Zhenru WangDepartment of Neurology, Shanghai Pudong Hospital and Department of Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Xuanming ShiDepartment of Biochemistry, School of Basic Medical Sciences, Anhui Medical University, Hefei, 230032, China.
Congcong QiDepartment of Laboratory Animal Science, Fudan University, Shanghai, 200032, China.
Song QinDepartment of Neurology, Shanghai Pudong Hospital and Department of Histoembryology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.ORCID 0000-0002-5569-4324

Funding

Fudan UniversityNational Key Research and Development Program of China 2014CB965001National Natural Science Foundation of China 31871477National Natural Science Foundation of China 32170971Natural Science Foundation of Shanghai Municipality 18ZR1403800
6 · The paper itself

Abstract

The hippocampus, a brain region that is crucial for cognitive learning, memory and emotional regulation, undergoes its primary development during embryonic and early postnatal stages. Krüppel-like factor 7 (KLF7), a transcription factor associated with autism spectrum disorder and intellectual developmental disorders, plays a pivotal role in brain development. In this study, we investigated the role of KLF7 in hippocampal development using conditional knockout mice [Emx1-Cre;Klf7Flox(F)/F]. We found that KLF7 deletion in hippocampal progenitors resulted in significant hippocampal shrinkage, disrupting neurogenesis, neuronal differentiation and migration. KLF7 mutant mice exhibited abnormal neuronal projections, anxiety- and depression-like behaviors, and memory impairments. Transcriptomic profiling identified Draxin, a neural chemorepellent, as a key downstream target of KLF7. Remarkably, overexpression of Draxin rescued dentate gyrus granule cell migration defects in KLF7 mutant mice. These findings demonstrate that KLF7 is essential for proper hippocampal development and function, regulating neuronal migration through Draxin. This study provides mechanistic insights into the neurological deficits associated with KLF7 pathogenic variants and highlights potential therapeutic targets for neurodevelopmental disorders.

Indexed as

Cell MovementHippocampusKruppel-Like Transcription FactorsNeurogenesisNeuronsAnimalsCell DifferentiationDentate GyrusMiceMice, KnockoutKlf7 protein, mouseKruppel-Like Transcription FactorsDraxinHippocampusKrüppel-like factor 7MouseNeurogenesisNeuronal migrationNeuronal projections

Identifiers

PMID40762575
PMCPMC12377812

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.