ArticleClinical and experimental dental research2025
Evaluation of 3D-Printed Polylactic Acid as a Bone Substitute: An Animal Study in a Rat Model.
Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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5 authors.
Funding
Abstract
objectivesBone repair and regeneration are important processes for treating bone defects and injuries. However, traditional bone grafts like autografts and allografts have limitations, such as complications at the donor site and immune rejection. As a result, there is growing interest in using polylactic acid (PLA), a biodegradable and biocompatible material, as a synthetic bone substitute. This study aims to evaluate the effectiveness of 3D-printed PLA scaffolds as bone substitutes using a rat model. MATERIAL AND
methodsPLA scaffolds with dimensions of 2 × 2 × 4 mm and 2 × 2 × 8 mm were fabricated using the CUBEX-TRIO 3D printer. Twelve male Wistar rats were divided into four groups based on defect size (4 and 8 mm) and observation period (4 weeks and 8 weeks). The surgical procedures involved creating discontinuity defects in the rats' zygoma and implanting PLA scaffolds that were stabilized with a bio-membrane. Bone regeneration was assessed through radiographic analysis and histological examination.
resultsRadiographic analysis confirmed the formation of bone in the grafted regions. Histological analysis revealed connective tissue formation at the defect edges and scaffold surface at both 4 and 8 weeks. In the 4 mm defect group, the transformation of connective tissue into chondrocytes and endochondral ossification was observed at 8 weeks, indicating successful bone regeneration. However, in the 8 mm defect group, bone formation was not as evident, suggesting limitations in the osteoinductive potential of PLA scaffolds for larger defects.
conclusionsThe 3D-printed PLA scaffolds show promise as bone substitutes for small to moderate-sized defects due to their effective biocompatibility and osteoinductive potential. Further studies are needed to optimize their performance for larger defects, potentially enhancing their clinical application in bone repair and regeneration.
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