Evidence map›Paper›PMID 40764335›Full record

ArticleScientific reports2025

P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions.

Elpida Tsonou, Julia Y Chu, Polly A Machin, Anna G Roberts, Anne Segonds-Pichon, David Baker, David C Hornigold, Heidi C E Welch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elpida Tsonou *Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Julia Y Chu *Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Polly A Machin *Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Anna G RobertsSignalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.
Anne Segonds-PichonBioinformatics Facility, The Babraham Institute, Cambridge, UK.
David BakerBioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
David C HornigoldBioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Heidi C E WelchSignalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. heidi.welch@babraham.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/P013384/1
6 · The paper itself

Abstract

P-Rex2 is a Rac guanine-nucleotide factor (Rac-GEF) that controls glucose homeostasis. This role is thought to be mediated through its adaptor function inhibiting Pten rather than through its Rac-GEF activity, but this remains to be demonstrated. To examine this question, we have investigated the roles of P-Rex2 in glucose homeostasis using Prex2

Indexed as

GlucoseGuanine Nucleotide Exchange FactorsLiverMuscle, SkeletalAnimalsHepatocytesHomeostasisInsulinInsulin ResistanceMiceMice, KnockoutReceptors, G-Protein-CoupledGlucoseGuanine Nucleotide Exchange FactorsInsulinReceptors, G-Protein-CoupledGlucose homeostasisGpr21G protein-coupled receptor (GPCR)Guanine-nucleotide exchange factor (GEF)LiverMitochondriaP-Rex1P-Rex2Skeletal muscle

Identifiers

PMID40764335
PMCPMC12325715

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.