SynthesisUrologie (Heidelberg, Germany)2026
[Gender-specific differences in outcome and survival in early cystectomy : Systematic review].
Synthesis in Urologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
backgroundDespite a lower incidence, women with bladder cancer have poorer survival rates than men. However, studies to date have provided insufficient data on gender-specific treatment outcomes, particularly after radical early cystectomy for Bacillus Calmette-Guérin (BCG) failure.
objectivesAre there gender-specific differences in oncologic outcomes and complication rates after radical early cystectomy in patients with nonmuscle invasive bladder cancer after failure of BCG instillation therapy? MATERIALS AND
methodsA systematic literature search was conducted in MEDLINE and the Cochrane Library in January 2025. The complete study protocol has been prospectively registered at PROSPERO (ID CRD42024611111).
resultsThree retrospective cohort studies with a total of 655 patients (18.8% of whom were women) were included. There were no significant gender-specific differences in terms of overall survival, cancer-specific survival, or progression. Data on complications and quality of life were limited or not available. In two studies, prostatic urethral involvement was identified as a negative prognostic marker in men.
conclusionThe current evidence base is sparse, methodologically limited, and biased by the underrepresentation of women. Therefore, it is not possible to make reliable statements on the effect of gender on the efficacy of early cystectomy after BCG failure. Further research on gender-dependent risk factors, especially hormonal and immunological influences, is urgently needed to develop personalized treatment strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.