Evidence map›Paper›PMID 40764482›Full record

ArticleNPJ Parkinson's disease2025

GABA outperforms iron and neuromelanin in detecting nigrostriatal alterations in early-stage Parkinson's disease with RBD.

Youmin Zhang, Pei Huang, Peng Liu, Yan Li, Zhijia Jin, Qiurong Yu, Xiaofeng Shi, Yu Liu, Zenghui Cheng, Peng Wu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Youmin Zhang *Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Pei Huang *Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peng LiuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan LiDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhijia JinDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiurong YuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaofeng ShiDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu LiuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zenghui ChengDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Peng WuPhilips Healthcare, Shanghai, China.
Jinyuan WengPhilips Healthcare, Shanghai, China.
Fangtao LiuDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ewart Mark HaackeDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying CuiDepartment of Radiology, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Shengdi ChenDepartment of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chensd@rjh.com.cn.
Naying HeDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hny12267@rjh.com.cn.
Fuhua YanDepartment of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yfh11655@rjh.com.cn.

Funding

National Natural Science Foundation of China 82271954National Natural Science Foundation of China 82471949Natural Science Foundation of Shanghai 24ZR1446600
6 · The paper itself

Abstract

This study aimed to examine variations in iron deposition, neuromelanin (NM) content, gamma-aminobutyric acid (GABA) and glutamate-glutamine complex (Glx) levels within the nigrostriatal pathway in early-stage Parkinson's disease (PD) patients with and without Rapid Eye Movement Sleep Behavior Disorder (RBD). Twenty-two early-stage PD patients with RBD (PD-RBD), 33 without RBD (PD-nRBD), and 36 healthy controls (HC) were prospectively recruited and underwent 3 T MRI and

Identifiers

PMID40764482
PMCPMC12325966

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.