ArticleBMC veterinary research2025
An olive oil-derived NAE mixture (Olaliamid
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Correction: An olive oil-derived NAE mixture (OlaliamidBMC veterinary research · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
backgroundCanine obesity is a common disorder accompanied by a low-grade chronic inflammation and is considered a risk factor for liver and heart diseases. The present study aimed to investigate whether an olive oil-derivative enriched in N-acylethanolamines (Olaliamid
resultsTwenty-seven dogs of mixed breed and size with a body condition score ≥ 7/9 were included in the trial, once provided they were otherwise healthy. Dogs were fed a commercial maintenance diet for two weeks before enrolment, and randomized in two groups, i.e., OLA (n = 14) and placebo (OLA vehicle; n = 13). Both treatments were administered orally by the owners in a liquid form at 0.7 ml/5kg body weight, once a day for three months. At baseline and three months later dogs underwent physical examination, blood draw, and echocardiography. At the same timepoints, owners were given a questionnaire about their dog's general condition. OLA prevented the increase in leptin observed in the placebo group (P = 0.011), decreased IL-6 (P = 0.043) and derivatives-reactive oxygen metabolites (d-ROMs, P = 0.008), and increased biological antioxidant potential (BAP) compared to the placebo group (P = 0.032). Moreover, OLA protected the liver, with ALT levels being decreased in the OLA group compared to the placebo one (P = 0.005) and bilirubin levels being decreased in the OLA group (P = 0.030) but not in the placebo one. OLA showed a cardioprotective effect, with a significant decrease of IVSdN (P = 0.028), LVPWdN (P = 0.047), IVSd/LVIDd (P = 0.015) and LVPWd/LVIDd (P = 0.034) compared to the placebo group. According to dog owners, the difficulty rising from lying down significantly increased in the placebo group (P = 0.039) but not in the OLA one.
conclusionOverall, OLA improved obesity-induced meta-inflammation and oxidative status and helped to ameliorate liver and heart health as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.