ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
The effect of the "exposome" on developmental brain health and cognitive outcomes.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep as a potential link between exposome, mental health and cognitive development in children and adolescents - a scoping review.Archives of public health = Archives belges de sante publique · 2026Pooled it
- Adverse policing as a social exposome pathway: Implications for depression, cognition, and dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Multivariate environmental exposures are reflected in whole-brain functional connectivity and cognition in youth.Developmental cognitive neuroscience · 2026Article
- Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026Review
- Childhood environment clusters reveal heterogeneous associations between large-scale brain networks and youth mental health symptoms.Psychological medicine · 2026Article
- Menarche onset is an inflection point for mental health and brain development.bioRxiv : the preprint server for biology · 2026Article
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- The puzzle of heterogeneity: an introduction to part II.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Integrated assessment of environmental infrastructural and social risks for urban public safety.Scientific reports · 2026Article
- Trajectories of mental health and mental illness: where we are now and where we go next.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Physical Activity, Cognitive Function, and Learning Processes: The Role of Environmental Context.Behavioral sciences (Basel, Switzerland) · 2025Article
- The PAthways to Resilience And Mental health (PARAM) project: protocol for a multi-site developmental cohort in India.BMC psychiatry · 2025Article
- The hidden pathways to internalized weight bias: from insecure attachment to depressive self-schemas.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Each child's unique environment and experiences play a crucial role in shaping neurodevelopment and cognitive outcomes. Though a long history of prior research has highlighted the importance of numerous aspects of early life environments, including physical/chemical, psychosocial, socioeconomic, and cultural factors, it remains challenging to fully capture an individual's complete set of varied exposures, experiences, and external environments ("exposome") in a single study. The growing field of "exposomics" aims to overcome these challenges by leveraging interdisciplinary ideas and diverse methodologies to assess the additive and interactive effects of multimodal environmental features in relation to health outcomes. Here, we expand upon prior theories to describe a conceptual framework for leveraging exposomics in studies of brain health and cognitive functioning, including the outsized role of environmental influences during sensitive windows of neurodevelopmental plasticity in childhood and adolescence. We also describe current methodologies for the measurement and analysis of the exposome and suggest new ways to apply these methods in future work. Efforts to quantify the exposome in large-scale samples of youth have already begun to yield important new insights regarding environmental impacts on cognitive neurodevelopment and hold great promise for future work aiming to support healthy development in youth.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.