Observational studyColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2025
Clinical Frailty Scale predicts overall survival after colon cancer surgery in people aged 80 years and older: A prospective multicentre observational study.
Observational study in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Long-Term Functional Outcomes After Prehabilitation in Frail Older Adults Undergoing Colorectal Cancer Surgery: A One-Year Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Clinical Frailty Scale predicts overall survival after colon cancer surgery in people aged 80 years and older: A prospective multicentre observational study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimAn increasing number of elective colon cancer surgeries are performed on older patients. Frail patients are at a higher risk of postoperative adverse events and early mortality. This prospective, multicentre, observational study aimed to analyse preoperative screening tools and the long-term survival of older patients having elective colon cancer surgery. The focus was on patients who survived more than 3 months postoperatively, excluding the effect of early postoperative mortality.
methodsPatients aged ≥80 years with electively operated stage I-III colon cancer were recruited. Prospectively collected data included comorbidities, functional and frailty status, postoperative outcomesand long-term survival. Univariate and multivariable Cox regression analyses were conducted to determine factors associated with long-term survival.
resultsA total of 227 surgical patients were included. Survival rates at 1 and 3 years were 94% and 74% for all patients and 86% and 57% for patients with Clinical Frailty Scale (CFS) 5-9, respectively. In multivariable regression analysis, CFS 5-9 (HR 3.16, 95% CI 1.31-7.63, p = 0.011) and tumour stage III (HR 2.50, 1.16-5.39, p = 0.020) were the patient-related variables affecting survival among those surviving over 3 months postoperatively.
conclusionsPreoperative frailty assessed by CFS predicts long-term survival in older patients after curative colon cancer surgery.
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Registered trials
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