Evidence map›Paper›PMID 40765016›Full record

ArticleAutophagy2025

The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection in

Chia-Heng Hsu, Yi-Jhan Li, Ting-Ni Guo, Fei-Yang Tzou, Cheng-Li Hong, Chin-Hsien Lin, Shu-Yi Huang, Chih-Chiang Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chia-Heng HsuGraduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.
Yi-Jhan LiGraduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.
Ting-Ni GuoGraduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.
Fei-Yang TzouGraduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-3463-1436
Cheng-Li HongGraduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.
Chin-Hsien LinDepartment of Neurology, National Taiwan University Hospital, Taipei, Taiwan.ORCID 0000-0001-8566-7573
Shu-Yi HuangDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Chih-Chiang ChanGraduate Institute of Physiology, National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-2626-3805

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagic decline accompanies age and causes a deterioration in proteostasis, rendering neuronal demise. Rab27 functions as a vesicle regulator for macroautophagic/autophagic degradation and exocytosis. Loss of

Indexed as

Drosophila melanogasterDrosophila ProteinsLongevityNeuroprotectionrab27 GTP-Binding Proteinsrab GTP-Binding Proteinsalpha-SynucleinAnimalsAutophagyErbB ReceptorsNeuronsProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine Kinasesalpha-SynucleinDrosophila ProteinsErbB ReceptorsProto-Oncogene Proteins c-aktrab27 GTP-Binding Proteinsrab GTP-Binding ProteinsTOR Serine-Threonine KinasesAutophagybrain-fat body axisEgfrlifespanparkinson diseaseRab27

Identifiers

PMID40765016
PMCPMC12758210

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.