ArticlePhysical activity and nutrition2025
Effect of exercise on the human gut microbiota in individuals with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials.
Article in Physical activity and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Microbial engraftment and immune regulation during fecal microbiota transplantation and immune checkpoint inhibitor therapy.Nature communications · 2026Review
- A Pilot Longitudinal 16S rRNA Gene Sequencing Study Exploring the Relationship Between Gut Microbiota and Body Composition in Healthy Adults.Polish journal of microbiology · 2026Article
- Ampelopsis Grossedentata Flavonoids Alleviate Hepatic Damage Through Remodeling Intestinal Microflora and Reducing Oxidative Stress in Rats.Food science & nutrition · 2026Article
- Precision nutrition targeting the gut microbiota for weight management: mechanisms and applications.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeObesity and its associated comorbidities, including chronic inflammation, pose significant public health challenges. Recent studies have suggested a link between obesity and gut microbial dysbiosis, with exercise emerging as a potential modulator of gut microbiota by enhancing microbial diversity and short-chain fatty acid (SCFA) production. However, the effects of exercise on the microbiome diversity and composition in overweight individuals or with obesity remain inconsistent.
methodsThis study systematically reviewed literature from PubMed, Embase, Cochrane Library, and ScienceDirect databases up to November 5, 2024, following PRISMA guidelines. Eleven studies were included in the systematic review, and four studies with quantitative data were analyzed using meta-analysis (Comprehensive Meta-Analysis software) and the ROB tool.
resultsThe meta-analysis showed a statistically significant effect of exercise on beta diversity. The pooled effect size for Bray-Curtis dissimilarity was 4.56 (95% confidence interval (CI) [1.77, 11.80], Z = 3.14, P = 0.002). These findings suggest that exercise positively influences gut microbial structure in overweight individuals or with obesity.
conclusionExercise may be a key component of lifestyle modification to modulate the gut microbiota and improve metabolic health in overweight individuals or with obesity. Future studies should evaluate the independent effects of fitness improvement and weight loss on gut microbial composition by employing multi-omics and metabolic pathway analyses to develop personalized obesity management strategies.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.