ArticleAnnals of medicine2025
Association of exposure duration, modality, and polycythaemia with hyperuricaemia among han male immigrants at high altitudes: a cross-sectional study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The role of the gut microbiota-uric acid metabolism axis in high-altitude hyperuricemia: dysregulation mechanisms, pathway associations and therapeutic perspectives.Frontiers in microbiology · 2026Review
- High-altitude hyperuricemia: a double-edged sword of adaptation and maladaptation.Frontiers in public health · 2026Review
- Low initial body fat percentage exacerbates skeletal muscle loss and increases the risk of hyperuricemia during high-altitude acclimatization in young men.Frontiers in nutrition · 2026Article
- Development and psychometric validation of a core competency scale for military nurses in high-altitude extreme environments.Frontiers in medicine · 2026Article
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Authors and funding
10 authors.
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Abstract
backgroundHyperuricaemia is associated with increased metabolic syndrome, cardiovascular disease, and mortality risk in the adult population and is more common in plateau areas. Han male immigrants are a high-risk population and deserve more attention. The correlations between different altitude exposure durations and exposure modalities with hyperuricaemia have not yet been reported.
methodsIn this cross-sectional study, qualified subjects were selected from two units on the Qinghai-Tibet Plateau and underwent a questionnaire survey (age, altitude exposure time, altitude exposure form), anthropometric measurements (body mass index [BMI], blood pressure [BP], and heart rate [HR]), and laboratory tests (white blood cell count [WBC], haemoglobin [HB], platelet count [PLT], and serum uric acid [SUA]). Univariate and multivariate logistic regression models were used to detect factors associated with hyperuricaemia.
resultsThe overall prevalence of hyperuricaemia was 40.8% (73 cases) among 179 Han male immigrants. Multivariate logistic regression analysis revealed that hyperuricaemia was significantly related to altitude exposure time (OR 6.744, 95% CI 1.263-36.019), altitude exposure form (OR 2.580, 95% CI 1.068-6.231) and high-altitude polycythaemia (OR 2.125, 95% CI 1.011-4.465).
conclusionHigh-altitude polycythaemia, exposure to high altitudes for 1-5 years, and long-term exposure to the same high-altitude areas when the high-altitude exposure dose is equal are important factors associated with hyperuricemia.
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