ArticleJournal of veterinary science2025
PCR-based detection of hereditary mutations in
Article in Journal of veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
importanceUnderstanding the susceptibility of native Korean dogs to genetic diseases is important for animal welfare and breeding. However, little is known regarding the segregation of genetic variations associated with genetic diseases among native Korean dog breeds, highlighting the need for further research in this area.
objectiveA genome-wide analysis was conducted using the available whole genome sequencing (WGS) results of DongGyeongi, Sapsaree, and Jindo dogs to evaluate the presence of disease-associated mutations and develop polymerase chain reaction (PCR)-based typing methods.
methodsUsing WGS data from 32 individuals of DongGyeongi, Sapsaree, and Jindo dogs, variant calling was used to identify variants associated with canine genetic diseases in Online Mendelian Inheritance in Animals. Additionally, allele-specific PCR-based typing methods for the identified mutations were developed.
resultsFour different variants were identified: NC_006583.3:g.54192143C>G in the CONCLUSIONS AND RELEVANCE: Genome-wide analysis was conducted to identify the causative mutations of genetic diseases in native Korean dogs. The observed frequencies of the identified variants differed among native Korean dog breeds. The typing methods used to detect variant alleles in this study will contribute to improving the genetic robustness of native Korean dog breeds.
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