Evidence map›Paper›PMID 40765526›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

Time-Restricted Feeding Attenuates Salt-Sensitive Hypertension and Renal Damage.

Lauren Yunker, Kristie Usa, Adaysha C Williams, John J Reho, Justin L Grobe, Michelle L Gumz, Alison J Kriegel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lauren YunkerDepartment of Physiology (L.Y., K.U., A.C.W., J.J.R., J.L.G., A.J.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0003-1901-6486
Kristie UsaDepartment of Physiology (L.Y., K.U., A.C.W., J.J.R., J.L.G., A.J.K.), Medical College of Wisconsin, Milwaukee.ORCID 0009-0000-0083-2091
Adaysha C WilliamsDepartment of Physiology (L.Y., K.U., A.C.W., J.J.R., J.L.G., A.J.K.), Medical College of Wisconsin, Milwaukee.
John J RehoDepartment of Physiology (L.Y., K.U., A.C.W., J.J.R., J.L.G., A.J.K.), Medical College of Wisconsin, Milwaukee.
Justin L GrobeDepartment of Physiology (L.Y., K.U., A.C.W., J.J.R., J.L.G., A.J.K.), Medical College of Wisconsin, Milwaukee.ORCID 0000-0001-9737-0873
Michelle L GumzDepartment of Physiology and Aging; Center for Integrative Cardiovascular and Metabolic Disease, Department of Medicine, Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville (M.L.G.).ORCID 0000-0002-1342-0878
Alison J KriegelDepartment of Physiology (L.Y., K.U., A.C.W., J.J.R., J.L.G., A.J.K.), Medical College of Wisconsin, Milwaukee.

Funding

INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Interaction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4M
Impact of Early Life Sodium Intake on Growth and Metabolism – Role of Hypothalamic MechanismsR01DK133121 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI GROBE, JUSTIN L, SEGAR, JEFFREY L · 2022 to 2025
$1.9M
Effect of High Salt Diet on Proximal Tubular Sodium Reabsorption, Metabolic Stress, and InjuryR56DK135598 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI KRIEGEL, ALISON J · 2023 to 2023
$100k
NHLBI NIH HHS R01 HL134850NHLBI NIH HHS T32 HL007852NIDDK NIH HHS R01 DK133121NIDDK NIH HHS R56 DK135598
6 · The paper itself

Abstract

backgroundTime-restricted feeding (TRF), a type of intermittent fasting, has been shown to improve blood pressure; however, there is limited data on its effects in salt-sensitive (SS) hypertension. We hypothesized that TRF intervention would attenuate the progression of hypertension and renal damage in Dahl SS rats on a high-salt diet.

methodsChronic 24-hour femoral mean arterial pressure (MAP) was recorded during 1 week of ad libitum low-salt or high-salt feeding, followed by 1 week of ad libitum feeding or TRF (16 hours fasting: 8 hours ad libitum) of the same diet. Cosinor analysis was performed on MAP traces. Comprehensive metabolic phenotyping was performed during the second week of the study. Sodium excretion and creatinine clearance were assessed in 4-hour windows over the final study day.

resultsRats on high salt developed higher blood pressure during week 1. Implementation of TRF during week 2 blunted further increases in MAP. Reduced MAP during the active phase was responsible for the lower 24-hour MAP in TRF rats. In rats on TRF, the respiratory exchange ratio was reduced during fasting without altering daily sodium intake or body weight. On the final study day, high-salt TRF rats exhibited time-dependent differences in sodium excretion and creatinine clearance.

conclusionsThe TRF regimen attenuated SS hypertension and renal damage in male SS rats on a high-salt diet without altering sodium intake or body weight. If these findings translate clinically, TRF may provide an alternative to a salt-restricted diet for management of SS hypertension.

Indexed as

Blood PressureFastingHypertensionKidneyKidney DiseasesSodium Chloride, DietaryAnimalsDisease Models, AnimalMaleRatsRats, Inbred DahlTime FactorsSodium Chloride, Dietaryblood pressurediethypertensionratssodium

Identifiers

PMID40765526
PMCPMC12673638

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.