Evidence map›Paper›PMID 40765830›Full record

ReviewInternational journal of biological sciences2025

New insights into coordinated regulation of AHR promoter transcription; molecular mechanisms and therapeutic targets.

Kenly Wuputra, Chia-Che Ku, Wen-Hung Hsu, Tusty-Jiuan Hsieh, Yi-Chun Tsai, Chih-Yen Chen, Yoshiharu Tanaka, Ying-Chu Lin, Chao-Hung Kuo, Deng-Chyang Wu and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kenly WuputraCell Therapy Research Center, Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Chia-Che KuCell Therapy Research Center, Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Wen-Hung HsuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Tusty-Jiuan HsiehGraduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Yi-Chun TsaiDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Chih-Yen ChenInstitute of Emergency and Critical Medicine, and School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan.
Yoshiharu TanakaRadiation Biology and Molecular Genetics, Division of Quantum Radiation, Faculty of Technology, Osaka Metropolitan University, Osaka 599-8531, Japan.
Ying-Chu LinSchool of Dentistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Chao-Hung KuoDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Deng-Chyang WuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.
Kazunari K YokoyamaCell Therapy Research Center, Department of Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AHR) plays crucial roles in the control of stress, xenobiotic metabolism, inflammation, and cancer. However, information on the chromatin regulation of ligand-dependent

Indexed as

Promoter Regions, GeneticReceptors, Aryl HydrocarbonTranscription, GeneticAnimalsHumansNF-E2-Related Factor 2Reactive Oxygen SpeciesSignal TransductionNF-E2-Related Factor 2Reactive Oxygen SpeciesReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorchromatin controlJun dimerization proteinnuclear factor erythroid 2-related factor 2reactive oxygen speciestranscriptional regulation

Identifiers

PMID40765830
PMCPMC12320239

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.