ArticleFrontiers in medicine2025
Topical EOSSKY fullerene moisturizing and repairing cream for preventing acute radiation dermatitis in breast cancer patients undergoing radiotherapy: a randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of moisturizers on acute radiation dermatitis: A systematic review and meta-analysis.Medicine · 2026Pooled it
- Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Purpose: Acute radiation dermatitis (ARD) is a prevalent complication among breast cancer patients undergoing radiotherapy. Fullerene possesses broad-spectrum free radical scavenging properties, which may be beneficial in mitigating oxidative stress. This study aimed to evaluate the impact of fullerene on both the incidence and severity of ARD in breast cancer patients. Methods: This study involved 88 breast cancer patients who met the inclusion criteria. Participants were randomly assigned to either the fullerene group or the control group in a 1:1 ratio. The primary endpoint was the grading of ARD and the cumulative dose of ionizing radiation at the first occurrence of ARD. Secondary endpoints included patient-reported symptoms, such as pain and quality of life (QoL). Results: The Radiation Therapy Oncology Group (RTOG) score was significantly lower in the fullerene group than in the control group, and the cumulative dose of ionizing radiation at the first occurrence of ARD was higher. There was a statistically significant difference between the two groups ( Conclusion: This trial indicated that fullerene could reduce the grading of ARD, delay the occurrence of ARD, alleviate patients' symptoms, and improve the patients' overall quality of life. Clinical trial registration: https://www.chictr.org.cn/index.html, identifier CTR2400079800.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.