Evidence map›Paper›PMID 40766358›Full record

ArticlebioRxiv : the preprint server for biology2025

Revealing the nervous system requirements of Alzheimer's disease risk genes in

Jennifer M Deger, Shabab B Hannan, Mingxue Gu, Colleen E Strohlein, Lindsey D Goodman, Sasidhar Pasupuleti, Zahid Shaik, Liwen Ma, Yarong Li, Jiayang Li and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Jennifer M DegerNeuroscience Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2208-3348
Shabab B HannanDepartment of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-8984-4773
Mingxue GuDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Colleen E StrohleinNeuroscience Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2634-0770
Lindsey D GoodmanDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0002-9255-3811
Sasidhar PasupuletiDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Zahid ShaikDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0009-0006-0270-9058
Liwen MaDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Yarong LiDepartment of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Jiayang LiDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Morgan C StephensDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Michal TyrlíkDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0002-4928-533X
Zhandong LiuDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0002-7608-0831
Ismael Al-RamahiDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.
Juan BotasDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0001-5476-5955
Chad A ShawDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0001-7267-5398
Oguz KancaDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0001-5438-0879
Hugo J BellenDuncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA.ORCID 0000-0001-5992-5989
Joshua M ShulmanDepartment of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.

Funding

Medical Scientist Training ProgramT32GM136611 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin J Frankfort, Katherine Yudeh King · 2020 to 2026
$10.0M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC · 2020 to 2026
$9.9M
Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila ModelsU01AG072439 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J, BOTAS, JUAN · 2021 to 2025
$8.4M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
Decoding the impact of sex differences on Alzheimer's disease riskR01AG074009 · NIA · BAYLOR COLLEGE OF MEDICINE · PI AL-RAMAHI, ISMAEL, LICHTARGE, OLIVIER · 2021 to 2025
$6.0M
A Comprehensive Resource for Manipulating the Drosophila GenomeR24OD031447 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUGO J BELLEN, Oguz Kanca · 2021 to 2026
$5.2M
Mutidisciplinary Training;Brain Disorders &DevelopmentT32NS043124 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SWANN, JOHN WILLIAM · 2002 to 2021
$4.6M
IMPACTS OF GLIAL LIPID DROPLETS ON OXIDATIVE STRESS AND NEURODEGENERATION IN ALZHEIMER'S DISEASER01AG073260 · NIA · BAYLOR COLLEGE OF MEDICINE · PI BELLEN, HUGO J · 2021 to 2025
$2.6M
INVESTIGATING THE ROLE OF THE CYTOSKELETON IN NEURODEGENERATIONF31NS129062 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI STEPHENS, MORGAN CATHERINE · 2022 to 2024
$143k
NIA NIH HHS R01 AG073260NIA NIH HHS R01 AG074009NIA NIH HHS U01 AG072439NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIGMS NIH HHS T32 GM136611NIH HHS R24 OD031447NINDS NIH HHS F31 NS129062NINDS NIH HHS T32 NS043124
6 · The paper itself

Abstract

Most Alzheimer's disease (AD) susceptibility genes have poorly understood roles in the central nervous system (CNS). To address this gap, we systematically characterized 100 conserved candidate AD risk genes using a cross-species strategy in the fruit fly,

Indexed as

amyloid-betafunctional genomicsgene expression patternsgenetic screenGWASKozak-GAL4T2A-GAL4tau

Identifiers

PMID40766358
PMCPMC12324250

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.