ArticlebioRxiv : the preprint server for biology2025
Distributed control circuits across a brain-and-cord connectome.
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Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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92 authors.
Alexander Shakeel BatesDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-1195-0445
Jasper S PhelpsDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0001-8033-258X
Minsu KimDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-0074-6684
Helen H YangDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0001-5140-9664
Arie MatsliahPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0009-0001-4490-2028
Zaki AjabiDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-4411-4005
Eric PerlmanYikes LLC, Baltimore, MD, USA.ORCID 0000-0001-5542-1302
Kevin M DelgadoDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0009-0006-7504-0826
Mohammed Abdal Monium OsmanDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0001-8606-6518
Christopher K SalmonPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0000-0002-5732-8117
Jay GagerPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.
Benjamin SilvermanPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0009-0002-7518-3465
Sophia RenauldDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-0128-3458
Matthew F CollieDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0003-3933-529X
Jingxuan FanDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0001-7860-4558
Diego A PachecoDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0003-1638-2376
Yunzhi ZhaoDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0009-0003-3021-2389
Janki PatelDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-8140-9347
Wenyi ZhangDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-0132-9794
Laia Serratosa CapdevillaAelysia LTD, Bristol, UK.ORCID 0000-0001-9167-0285
Ruairí J V RobertsAelysia LTD, Bristol, UK.ORCID 0000-0003-2216-1465
Eva J MunnellyAelysia LTD, Bristol, UK.ORCID 0000-0001-9284-9463
Nina GriggsAelysia LTD, Bristol, UK.ORCID 0009-0007-7769-7933
Helen LangleyAelysia LTD, Bristol, UK.ORCID 0000-0002-1418-2306
Borja Moya-LlamasAelysia LTD, Bristol, UK.ORCID 0009-0008-4560-2976
Ryan T MaloneyDepartment of Organismic and Evolutionary Biology,Harvard University, Cambridge, MA, USA.ORCID 0000-0002-6111-7822
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.
Amy R SterlingPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.
Marissa SorekPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0009-0008-7636-0746
Krzysztof KrukEyewire, Boston, MA, USA.ORCID 0009-0005-9305-7042
Nikitas SerafetinidisEyewire, Boston, MA, USA.ORCID 0009-0006-7752-6715
Serene DhawanPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0000-0002-2872-1948
Tomke StürnerNeurobiology Division, MRC Laboratory of MolecularBiology, Cambridge, UK.ORCID 0000-0003-4054-0784
Finja KlemmGenetics Department, Leipzig University, Leipzig,Germany.ORCID 0009-0005-3800-3244
Paul BrooksZoology Department, University of Cambridge, Cambridge,UK.ORCID 0000-0001-5998-6378
Ellen LesserDepartment of Molecular Genetics and Cell Biology,The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-7929-0503
Jessica M JonesDepartment of Neurobiology and Biophysics, Universityof Washington, Seattle, WA, USA.ORCID 0000-0003-3638-255X
Sara E Pierce-LundgrenDepartment of Neurobiology and Biophysics, Universityof Washington, Seattle, WA, USA.ORCID 0009-0009-4589-761X
Su-Yee LeeDepartment of Neurobiology and Biophysics, Universityof Washington, Seattle, WA, USA.ORCID 0000-0001-5160-9930
Yichen LuoDepartment of Neurobiology and Biophysics, Universityof Washington, Seattle, WA, USA.ORCID 0000-0002-2265-1117
Andrew P CookDepartment of Biology, West Virginia University,Morgantown, WV, USA.ORCID 0000-0002-4349-2880
Theresa H McKimDepartment of Biology, University of Nevada Reno,Reno, NV, USA.ORCID 0000-0002-8501-6487
Emily C KophsDepartment of Biological Sciences, Vanderbilt University,Nashville, TN, USA.ORCID 0009-0006-6287-7205
Tjalda FaltMax Planck Institute for Biological Intelligence,Martinsried, Germany.ORCID 0009-0006-9484-5048
Alexa M Negrón MoralesInstitute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0009-0001-2250-6905
Austin BurkePrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0009-0008-1005-4869
James HebditchPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.
Kyle P WilliePrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.
Ryan WilliePrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.
Sergiy PopovychZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0003-3445-5014
Nico KemnitzZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0002-0260-4532
Dodam IhZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0002-0295-8445
Kisuk LeeZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0001-5707-0155
Ran LuZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0002-2077-8165
Akhilesh HalageriZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0001-7367-4776
J Alexander BaeZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0002-4681-6342
Ben JourdanSchool of Informatics, University of Edinburgh,Edinburgh, UK.ORCID 0000-0001-9831-0098
Gregory SchwartzmanJapan Advanced Institute of Science and Technology(JAIST), Nomi, Japan.
Damian D DemarestMolecular Brain Physiology and Behavior, LIMES Institute,University of Bonn, Bonn, Germany.ORCID 0009-0008-9443-0306
Emily BehnkePrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.
Doug BlandEyewire, Boston, MA, USA.
Anne KristiansenEyewire, Boston, MA, USA.
Jaime SkeltonEyewire, Boston, MA, USA.
Tom StocksEyewire, Boston, MA, USA.
Dustin GarnerEyewire, Boston, MA, USA.
Farzaan SalmanDepartment of Biology, West Virginia University,Morgantown, WV, USA.ORCID 0009-0001-2937-807X
Kevin C DalyDepartment of Biology, West Virginia University,Morgantown, WV, USA.ORCID 0000-0002-9616-2770
Anthony HernandezEyewire, Boston, MA, USA.
Sandeep KumarPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0000-0001-7181-232X
BANC-FlyWire Consortium
Sven DorkenwaldAllen Institute for Brain Science, Seattle, WA,USA.ORCID 0000-0003-2352-319X
Forrest CollmanAllen Institute for Brain Science, Seattle, WA,USA.ORCID 0000-0002-0280-7022
Marie P SuverDepartment of Biological Sciences, Vanderbilt University,Nashville, TN, USA.ORCID 0000-0003-4491-6996
Lisa M FenkMax Planck Institute for Biological Intelligence,Martinsried, Germany.ORCID 0000-0001-8420-6361
Michael J PankratzMolecular Brain Physiology and Behavior, LIMES Institute,University of Bonn, Bonn, Germany.ORCID 0000-0001-5458-6471
Gregory S X E JefferisNeurobiology Division, MRC Laboratory of MolecularBiology, Cambridge, UK.ORCID 0000-0002-0587-9355
Katharina EichlerGenetics Department, Leipzig University, Leipzig,Germany.ORCID 0000-0002-7833-8621
Andrew M SeedsInstitute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0000-0002-4932-6496
Stefanie HampelInstitute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.ORCID 0000-0001-8287-549X
Sweta AgrawalSchool of Neuroscience, Virginia Tech, Blacksburg,VA, USA.ORCID 0000-0003-0547-4099
Meet ZandawalaDepartment of Biochemistry and Molecular Biology, University of Nevada Reno, Reno, NV, USA.ORCID 0000-0001-6498-2208
Thomas MacrinaZetta AI LLC, Sherrill, NY, USA.ORCID 0000-0002-0622-9338
Diane-Yayra AdjavonHHMI Janelia, Ashburn, VA, USA.ORCID 0009-0001-4702-0776
Jan FunkeHHMI Janelia, Ashburn, VA, USA.ORCID 0000-0003-4388-7783
John C TuthillDepartment of Neurobiology and Biophysics, Universityof Washington, Seattle, WA, USA.ORCID 0000-0002-5689-5806
Anthony AzevedoDepartment of Neurobiology and Biophysics, Universityof Washington, Seattle, WA, USA.ORCID 0000-0001-8318-9678
H Sebastian SeungPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0000-0002-8591-6733
Benjamin L de BivortDepartment of Organismic and Evolutionary Biology,Harvard University, Cambridge, MA, USA.ORCID 0000-0001-6165-7696
Mala MurthyPrinceton Neuroscience Institute, Princeton University,Princeton, NJ, USA.ORCID 0000-0003-3063-3389
Jan DrugowitschDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-7846-0408
Rachel I WilsonDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0001-8573-9266
Wei-Chung Allen LeeDepartment of Neurobiology, Harvard Medical School,Boston, MA, USA.ORCID 0000-0002-4618-295X
Funding
Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Jonathan E. Baker · 2012 to 2026
$58.0MProject-003UM1NS132253 · NINDS · ALLEN INSTITUTE · PI Forrest Christie Collman, Nuno Macarico da Costa · 2023 to 2026
$24.8MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MProject C: Neural basis of causal inference in continuous navigationU19NS118246 · NINDS · UNIVERSITY OF ROCHESTER · PI DEANGELIS, GREGORY C · 2020 to 2024
$12.0MCross-Modal Sensory Interactions, Processing, and Representation in the Drosophila BrainU01NS131438 · NINDS · CORNELL UNIVERSITY · PI COHEN, ITAI, COWAN, NOAH JOHN · 2023 to 2025
$5.8MDissemination of FlyWire, A Whole-Brain Connectomics ResourceU24NS126935 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2022 to 2026
$5.6MStructural Variation in Neuronal Circuits as a Basis for Functional and Behavioral IndividualityR01NS121874 · NINDS · HARVARD MEDICAL SCHOOL · PI DE BIVORT, BENJAMIN, HASSAN, BASSEM A · 2021 to 2025
$5.0MUncovering the Neural Mechanisms that Flexibly Link Sensory Processing to BehaviorR35NS111580 · NINDS · PRINCETON UNIVERSITY · PI Mala Murthy · 2019 to 2026
$5.0MBRAIN CONNECTS: An Integrative Connectomics Coordination Center (IC3)U24NS139927 · NINDS · ALLEN INSTITUTE · PI Forrest Christie Collman, Hongkui Zeng · 2025 to 2026
$4.7MTools to broaden access to high-throughput functional connectomicsRF1MH117808 · NIMH · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN, MACRINA, THOMAS · 2019 to 2019
$4.3MScalable integration of cell types and connectivity in the motor cortex of rodents and non-human primatesRF1MH128840 · NIMH · ALLEN INSTITUTE · PI COLLMAN, FORREST CHRISTIE, MACARICO DA COSTA, NUNO · 2021 to 2021
$4.2MNeural coding of leg proprioceptionR01NS102333 · NINDS · UNIVERSITY OF WASHINGTON · PI John Tuthill · 2017 to 2026
$3.6MNIGMS NIH HHS P20 GM103440NIGMS NIH HHS T32 GM144273NIMH NIH HHS RF1 MH117808NIMH NIH HHS RF1 MH117815NIMH NIH HHS RF1 MH128840NINDS NIH HHS K99 NS129759NINDS NIH HHS R00 NS117657NINDS NIH HHS R01 NS102333NINDS NIH HHS R01 NS121874NINDS NIH HHS R01 NS121911NINDS NIH HHS R01 NS140174NINDS NIH HHS R35 NS111580NINDS NIH HHS RF1 NS128785NINDS NIH HHS U01 NS131438NINDS NIH HHS U19 NS118246NINDS NIH HHS U24 NS126935NINDS NIH HHS U24 NS139927NINDS NIH HHS UM1 NS132253Wellcome Trust
Abstract
Just as genomes revolutionized molecular genetics, connectomes (maps of neurons and synapses) are transforming neuroscience. To date, the only species with complete connectomes are worms
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.