ArticlebioRxiv : the preprint server for biology2025
Tau conveys intrinsic hyperactivity of VTA dopamine neurons but an inability to sustain burst firing.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionVentral tegmental area (VTA) dopamine has been implicated in neuropsychiatric symptoms observed in Alzheimer's disease (AD) patients. Dopaminergic dysfunction and aberrant firing are observed in mouse AD models, but the specific roles of Aβ and tau have not been determined.
methodsWe performed electrophysiological recordings of single VTA dopamine neuron firing in the 3xTg-AD model, followed by recordings in amyloid (APP
resultsDISCUSSION: These results suggest that hTau specifically induces hyperexcitable states within individual dopamine neurons, disrupting burst firing. This dopaminergic dysfunction could compromise reward learning and contribute to the psychiatric symptoms observed in AD.
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