Evidence map›Paper›PMID 40766465›Full record

ArticlebioRxiv : the preprint server for biology2025

HNRNPH1-mediated splicing events regulate

Tayvia Brownmiller, Soumya Sundara Rajan, Tamara L Jones, Patricio Pichling, Vernon J Ebegboni, Ashish Lal, Ioannis Grammatikakis, Erica C Pehrsson, Natasha J Caplen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tayvia BrownmillerFunctional Genetics Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0003-2627-0458
Soumya Sundara RajanFunctional Genetics Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0001-8346-9741
Tamara L JonesFunctional Genetics Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.
Patricio PichlingFunctional Genetics Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-3051-9458
Vernon J EbegboniFunctional Genetics Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-1898-6555
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-4299-8177
Ioannis GrammatikakisRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-8455-1584
Erica C PehrssonOmics Bioinformatics Facility, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-2968-6179
Natasha J CaplenFunctional Genetics Section, Genetics Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-0001-9460

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCI NIH HHS 75N91019D00024
6 · The paper itself

Abstract

HNRNPH1 is a regulator of alternative splicing, but few studies have defined the splicing events it mediates. Here, we used short- and long-read RNA sequencing to interrogate the transcriptome-wide effects of HNRNPH1 depletion and its regulation of specific splicing events. Differential alternative splicing analysis revealed effects on the transcriptome that involved all splice event categories. We confirmed HNRNPH1's regulation of a splicing event involving

Identifiers

PMID40766465
PMCPMC12324280

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.