Evidence map›Paper›PMID 40766492›Full record

ArticlebioRxiv : the preprint server for biology2025

OmniCellAgent: Towards AI Co-Scientists for Scientific Discovery in Precision Medicine.

Di Huang, Hao Li, Wenyu Li, Heming Zhang, Patricia Dickson, Ming Zhan, J Philip Miller, Carlos Cruchaga, Michael Province, Yixin Chen and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Di HuangInstitute for Informatics (I2).
Hao LiInstitute for Informatics (I2).
Wenyu LiComputer Science & Engineering.
Heming ZhangInstitute for Informatics (I2).ORCID 0000-0002-2025-9090
Patricia DicksonDepartment of Pediatrics, Washington University in St Louis, MO, USA.
Ming ZhanNational Institute of Drug Abuse, NIH, MD, USA.
J Philip MillerInstitute for Informatics (I2).
Carlos CruchagaNeuroGenomics and Informatics.ORCID 0000-0002-0276-2899
Michael ProvinceDivision of Statistical Genomics.
Yixin ChenComputer Science & Engineering.
Philip PayneInstitute for Informatics (I2).
Fuhai LiInstitute for Informatics (I2).

Funding

Vaccines and Therapeutic Antibodies to Respiro, Rubula, Peribunya and Phenuiviridae (R2P2)-ReVAMPPU19AI181984 · NIAID · WASHINGTON UNIVERSITY · PI MILLER, J. PHILIP · 2024 to 2024
$44.1M
Systems-Level Approach to Neuronopathic Lysosomal Storage DisordersRM1NS132962 · NINDS · WASHINGTON UNIVERSITY · PI JONATHAN D COOPER, PATRICIA I DICKSON · 2023 to 2026
$6.3M
AI models of multi-omic data integration for ming longevity core signaling pathwaysR33AG078799 · NIA · WASHINGTON UNIVERSITY · PI LI, FUHAI, PROVINCE, MICHAEL A. · 2025 to 2025
$1.5M
Modeling and targeting tumor-immune signaling interactions in tumor microenvironmentR01LM013902 · NLM · WASHINGTON UNIVERSITY · PI Fuhai Li · 2023 to 2026
$1.4M
Combine Genomics and Symptoms Data Driven Models to Discover Synergistic Combinatory Therapies for Alzheimer's DiseaseR56AG065352 · NIA · WASHINGTON UNIVERSITY · PI LI, FUHAI · 2020 to 2021
$986k
AI models of multi-omic data integration for ming longevity core signaling pathwaysR21AG078799 · NIA · WASHINGTON UNIVERSITY · PI LI, FUHAI, PROVINCE, MICHAEL A. · 2023 to 2023
$461k
NIAID NIH HHS U19 AI181984NIA NIH HHS R21 AG078799NIA NIH HHS R33 AG078799NIA NIH HHS R56 AG065352NINDS NIH HHS RM1 NS132962NLM NIH HHS R01 LM013902
6 · The paper itself

Abstract

The convergence of large language models (LLMs), AIagents, and large-scale omic datasets-such as single-cell omics, marks the arrival of a critical inflection point in biomedical research, via autonomous data mining and novel hypothesis generation. However, there is no specifically designed agentic AI model that can systematically integrate large-scale single-cell (sc) RNAseq (covering diverse diseases and cell types), omic data analytic tools, accumulated biomedical knowledge, and literature search to facilitate autonomous scientific discovery in precision medicine. In this study, we develop a novel agentic AI, OmniCellAgent, to empower non-computational-expert users-such as patients and family members, clinicians, and wet-lab researchers-to conduct scRNA-seq data-driven biomedical research like experts, uncovering molecular disease mechanisms and identifying effective precision therapies. The code of omniCellAgent is publicly accessible at: https://fuhailiailab.github.io/.

Identifiers

PMID40766492
PMCPMC12324537

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.