Evidence map›Paper›PMID 40766591›Full record

ArticlebioRxiv : the preprint server for biology2025

Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats.

Montana Kay Lara, Lieselot L G Carrette, Thiago Missfeldt Sanches, Oksana Polesskaya, Alicia Avelar, Angela Beeson, Hassiba Beldjoud, Brent Boomhower, Molly Brennan, Denghui Chen and 32 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

42 authors.

Montana Kay LaraDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-5810-4425
Lieselot L G CarretteDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Thiago Missfeldt SanchesDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6962-9569
Oksana PolesskayaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3024-114X
Alicia AvelarJamestown Community College, Olean, NY, USA.
Angela BeesonDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Hassiba BeldjoudDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Brent BoomhowerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Molly BrennanDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Denghui ChenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-6541-3418
Lindsey ChinaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Apurva S ChitreDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1709-9214
Dana Elizabeth ConliskThe Scripps Research Institute, La Jolla, CA, USA.
McKenzie FannonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Benjamin B JohnsonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-7269-5145
Elaine KeungDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0009-0003-4833-4093
Adam KimbroughPurdue University, West Lafayette, IN, USA.
Jenni KononoffThe Scripps Research Institute, La Jolla, CA, USA.
Angelica Renee MartinezDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Lisa MaturinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Khai-Minh NguyenDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Alex MorganDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Joseph MosqueraDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Dyar OthmanDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sonja L PlasilDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Jarryd RamborgerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Paul SchweitzerThe Scripps Research Institute, La Jolla, CA, USA.
Sharona SedighimDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Osborne SeshieDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Kokila ShankarDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Benjamin SichelDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sierra SimpsonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-1352-0617
Lauren Cassandra SmithDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Elizabeth A SneddonDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-4004-9434
Lani TieuDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Nathan VelardeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Selene ZahediDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Leah C Solberg WoodsDepartment of Internal Medicine, Section on Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-7943-798X
Marsida KallupiDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Giordano de GuglielmoDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-4782-7430
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3634-0747
Olivier GeorgeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-3700-5003

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI RICHARDS, JERRY B · 2014 to 2023
$27.4M
DP30DA060810 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Abraham A Palmer · 2024 to 2026
$5.6M
The role of structural variants and tandem repeats in substance abuse-related behavioral traitsU01DA051234 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GYMREK, MELISSA, PALMER, ABRAHAM A · 2021 to 2025
$3.5M
NIDA NIH HHS P30 DA060810NIDA NIH HHS P50 DA037844NIDA NIH HHS U01 DA051234
6 · The paper itself

Abstract

Background: Cocaine use disorder (CUD) is a major public health crisis with detrimental individual and societal effects. The specific genes mediating CUD remain largely unknown. Methods: We conducted a genome-wide association study (GWAS) using outbred N/NIH Heterogeneous Stock (HS; n = 836, female = 415, male = 421) rats. We examined multiple CUD-related phenotypes that captured acquisition of self-administration, escalation of intake, and compulsive-like responding. Results: Consistent with the existing literature, these traits were phenotypically and genetically correlated and exhibited modest heritability (h Conclusions: This is the largest genetic study of cocaine self-administration ever conducted in any species. Our results replicate previous loci associated with CUD in humans and provide several novel biological insights including the potential of pharmacological strategies targeting carboxylesterases for the treatment of CUD.

Indexed as

ces1cocainecocaine use disorderGWASHeterogeneous Stock ratsself-administration

Identifiers

PMID40766591
PMCPMC12324211

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.