ArticlebioRxiv : the preprint server for biology2025
Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling.
Valentina Botero, Jenifer Barrios, Anneke Knauss, Ethan Rosendahl, Kenneth J Colodner, Seth M Tomchik
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Valentina BoteroNeuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA.
Jenifer BarriosNeuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA.
Anneke KnaussNeuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA.
Ethan RosendahlNeuroscience and Pharmacology, University of Iowa, Iowa City, Iowa 52242, USA.
Kenneth J ColodnerProgram in Neuroscience and Behavior, Mount Holyoke College, South Hadley, MA 01075, USA.
Funding
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI KEVIN R COOK, THOMAS KAUFMAN · 2014 to 2026
$13.5MMechanisms of Nf1 Pathophysiology Underlying HyperactivityR01NS097237 · NINDS · UNIVERSITY OF IOWA · PI TOMCHIK, SETH M · 2017 to 2021
$2.4MDopaminergic circuit modulation of learning and arousal-mediated memory enhancementR01NS114403 · NINDS · UNIVERSITY OF IOWA · PI TOMCHIK, SETH M · 2020 to 2024
$2.0MGenetic and molecular mechanisms of Nf1-dependent neuronal regulation of metabolismR01NS126361 · NINDS · UNIVERSITY OF IOWA · PI Seth M Tomchik · 2022 to 2026
$2.0MMechanisms of compartmentalized plasticity in learning and memoryR01NS124716 · NINDS · UNIVERSITY OF IOWA · PI Seth M Tomchik · 2023 to 2026
$1.5MThe role of Nf1 in sleep-dependent regulation of metabolic functionR21NS124198 · NINDS · TEXAS A&M UNIVERSITY · PI KEENE, ALEX C, TOMCHIK, SETH M · 2021 to 2021
$465kNIH HHS P40 OD018537NINDS NIH HHS R01 NS097237NINDS NIH HHS R01 NS114403NINDS NIH HHS R01 NS124716NINDS NIH HHS R01 NS126361NINDS NIH HHS R21 NS124198
6 · The paper itselfAbstract
Neurofibromatosis type 1 results from mutations in the
Identifiers
PMID40766628
PMCPMC12324403
What Socratic holds
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