Evidence map›Paper›PMID 40766680›Full record

ArticlebioRxiv : the preprint server for biology2025

Chronic activation of a key exercise signal transducer, CaMKII, drives skeletal muscle aging and sarcopenia.

Michael R Bene, Tae Chung, William A Fountain, Giovanni Rosales-Soto, Erick Hernández-Ochoa, Corina Antonescu, Liliana Florea, Seeun J Jeong, Anne Le, Qian-Li Xue and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michael R BeneDivision of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Tae ChungDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
William A FountainDivision of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Giovanni Rosales-SotoDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Erick Hernández-OchoaDepartment of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
Corina AntonescuGenetic Resources Core Facility, Computational Bioanalysis Division, and Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Liliana FloreaGenetic Resources Core Facility, Computational Bioanalysis Division, and Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Seeun J JeongDivision of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Anne LeGigantest, Inc., Baltimore, Maryland, USA.
Qian-Li XueDivision of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Ahmet HokeDepartments of Neurology and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Peter AbadirDivision of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Qinchuan WangDivision of Geriatric Medicine and Gerontology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · JOHNS HOPKINS UNIVERSITY · 2003 to 2025
$6.1M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · 2022 to 2025
$4.0M
Multidisciplinary Rheumatology Training ProgramT32AR048522 · JOHNS HOPKINS UNIVERSITY · 2003 to 2025
$766k
Translational Aging Research Training ProgramT32AG058527 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$612k
Computational Methods to Characterize Alternative Splicing and Genetic Determinants from Heterogeneous Sequence DataR35GM156374 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$363k
Voltage sensor domain movements in skeletal muscle fiber activationR01AR075726 · UNIVERSITY OF MARYLAND BALTIMORE · 2025 to 2025
$330k
NIAID NIH HHS P30 AI094189NIAMS NIH HHS R01 AR075726NIAMS NIH HHS T32 AR048522NIA NIH HHS P30 AG021334NIA NIH HHS T32 AG058527NIGMS NIH HHS R01 GM129085NIGMS NIH HHS R35 GM156374
6 · The paper itself

Abstract

Sarcopenia, the age-related loss of muscle strength and mass, contributes to adverse health outcomes in older adults. While exercise mitigates sarcopenia by transiently activating calcium (Ca

Identifiers

PMID40766680
PMCPMC12324419

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.