ArticleFrontiers in cellular and infection microbiology2025
The J-shaped association between the ratio of neutrophil counts to prognostic nutritional index and mortality in ICU patients with sepsis: a retrospective study based on the MIMIC database.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of oral bacterial lysates on asthma control and immune parameters in children: evidence from an updated systematic review and meta-analysis of randomized trials.Frontiers in pharmacology · 2026Pooled it
- Stress-induced hyperglycemia and mortality of non-diabetic patients with sepsis: a meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Occupational therapy improves functional recovery and reduces delirium in critically ill adults with and without stroke: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Real-World Evidence of the Effectiveness and Safety of Biosynthetic Semaglutide in Type 2 Diabetes: A Multicentre Study From Pakistan.Diabetes, obesity & metabolism · 2026Article
- Prognostic Nutritional Index as a Predictor of 90-Day Mortality in Surgical Sepsis Patients with Acute Kidney Injury-A Retrospective Cohort Study Based on the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Association between estimated pulse wave velocity and 28-day all-cause mortality in septic patients: a multicenter retrospective study.BMC infectious diseases · 2026Article
- Investigation of factors influencing intravenous glucocorticoid treatment course in severe acute urticaria: A retrospective study.Medicine · 2026Article
- A prediction model for mortality risk in melioidosis patients based on clinical and laboratory indicators: A single-center retrospective study.PLoS neglected tropical diseases · 2026Article
- Association between prognostic nutritional index and mortality in patients with sepsis-associated delirium: a retrospective cohort study using the MIMIC-IV database.BMC nutrition · 2026Article
- Dynamic prognostic nutritional index and 28-day mortality in sepsis: a joint modeling analysis.Nutrition & metabolism · 2026Article
- Prognostic Nutritional Index (PNI) in Patients With Diabetes and Sepsis: A Cross-Sectional Study.Cureus · 2026Article
- Efficacy and safety of Oliceridine versus Sufentanil in postoperative analgesia for burn skin grafting: a machine learning and SHAP-based cohort study.Frontiers in medicine · 2026Article
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- Intraoperative hypothermia risk trajectories in patients undergoing video-assisted thoracoscopic surgery: a retrospective study.Frontiers in medicine · 2026Article
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- Baseline and dynamic CALLY index changes predict mortality in sepsis-associated acute kidney injury: a two-center retrospective cohort study.Frontiers in nutrition · 2026Article
- Article
- Neutrophil-Percentage-to-Albumin Ratio and Monocyte-to-Albumin Ratio: Utility of the Combined Biomarkers in the Prediction of 30-Day Mortality in Male Diabetes Patients Over 80 Years Old with Bloodstream Infections.Clinical interventions in aging · 2026Article
- Article
- Deep learning guided propofol ketamine dosing and inflammation trajectories in elderly burns.Frontiers in computational neuroscience · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The ICU faces persistent challenges with sepsis, marked by systemic inflammation and metabolic disruptions, often leading to poor outcomes. Despite advances, reliable biomarkers for predicting sepsis outcomes are needed. This study introduces a novel indicator combining neutrophil count and prognostic nutritional index (PNI) to improve predictive accuracy by addressing both inflammatory and nutritional-immune aspects. Methods: We conducted a retrospective cohort study analyzing data from the MIMIC-IV database, focusing on adults diagnosed with sepsis per Sepsis 3.0 criteria. We excluded those younger than 18, with ICU stays under 48 hours, multiple ICU admissions, or incomplete data. Participants' neutrophil counts/PNI ratios were calculated and correlated with 30, 60, and 90-day hospital and ICU mortality, utilising Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic spline (RCS) models and subgroup analysis. Results: We included 2,116 patients from 22,517 eligible cases. Survival analysis demonstrated lower survival probabilities for higher neutrophil counts/PNI ratios across all observed time windows. Cox regression models revealed a significant association between higher neutrophil counts/PNI ratios and increased short- to medium-term mortality. The restricted cubic spline regression models illustrated a J-shaped relationship between neutrophil counts/PNI and mortality. Conclusion: The neutrophil counts/PNI ratio is a promising prognostic biomarker for sepsis-related outcomes in ICU settings, offering improved risk stratification and potentially guiding therapeutic interventions. Further research is warranted to validate these findings across diverse populations.
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