ArticleFrontiers in psychiatry2025
Genetic correlations of alcohol consumption and alcohol use disorder with sex hormone levels in females and males.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Article
- Lifestyle factors affecting the pathogenesis of androgenetic alopecia: a literature review.Frontiers in public health · 2026Review
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7 authors.
Funding
Abstract
Background: Alcohol consumption behaviors and alcohol use disorder risk and presentation differ by sex, and are associated with blood concentrations of the steroid sex hormones, testosterone and estradiol, and their regulatory binding proteins, sex hormone binding globulin (SHBG) and albumin. Genetic variation is also associated with alcohol consumption, alcohol use disorder, and levels of these hormones and binding proteins. Methods: To assess the contribution of genetic factors to previously described phenotypic associations between alcohol-use traits and sex-hormone levels, we estimated genetic correlations (r Results: For alcohol consumption, we observed positive genetic correlation (i.e. genetic effects in the same direction) with SHBG in females (r Conclusions: Shared genetic effects might contribute to positive associations of alcohol consumption with albumin and between alcohol dependence and SHBG in males; however, most of the phenotypic associations between alcohol-use traits and levels of sex hormones and their binding proteins did not correspond to broadly shared genetic effects in the same direction. Some even corresponded to genetic effects in the opposite direction. Future studies of these traits should include GWAS on larger cohorts by sex and investigation of localized correlations of genetic effects and the relative contributions of heritable and environmental factors.
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