ArticleFrontiers in cardiovascular medicine2025
Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association between systemic inflammation-immune index and comorbidities in patients with ankylosing spondylitis: a cross-sectional study.Clinical rheumatology · 2026Article
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Authors and funding
9 authors.
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Abstract
Background: Observational studies have indicated a potential association between ankylosing spondylitis and elevated cardiovascular disease (CVD) risk. However, it remains uncertain whether this association reflects a causal association. Therefore, we conducted this Mendelian randomization to investigate the causal relationship between ankylosing spondylitis and CVD. Methods: We performed a two-sample Mendelian randomization analysis to establish a causal relationship between ankylosing spondylitis and the risk of six prevalent CVDs: hypertension, heart failure, atrial fibrillation, coronary heart disease, myocardial infarction, and peripheral artery disease. Furthermore, multivariate Mendelian randomization was employed to determine the influence of confounding factors. Results: Genetically predicted ankylosing spondylitis increased the risk of heart failure according to the Mendelian randomization analysis (OR = 1.02; 95% CI = 1.00-1.04; Conclusion: Genetically predicted ankylosing spondylitis increased the risk of heart failure, and the causality may partly be mediated by increased arterial stiffness.
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