Evidence map›Paper›PMID 40767555›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2025

Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon CCl

Carina Wagner, Kristina Košić, Dominik Bulfon, Johannes Breithofer, Alina Jamnik, Clara Zitta, Paula Horvat, Kim Bilweis, Michael Schupp, Robert Zimmermann and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon CClLiver international : official journal of the International Association for the Study of the Liver · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carina WagnerInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Kristina KošićInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Dominik BulfonInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.ORCID 0000-0001-7628-7368
Johannes BreithoferInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Alina JamnikInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Clara ZittaInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Paula HorvatInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Kim BilweisInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Michael SchuppCharité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pharmacology, Max Rubner Center (MRC) for Cardiovascular-Metabolic-Renal Research, Berlin, Germany.
Robert ZimmermannInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Ulrike TaschlerInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.ORCID 0000-0001-9000-1602
Achim LassInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.ORCID 0000-0002-8190-7151

Funding

Austrian Science Fund
6 · The paper itself

Abstract

BACKGROUND AND

aimsAdvanced liver disease leads to liver fibrosis that is characterised by the activation of non-parenchymal stellate cells, accumulation of extracellular matrix proteins, and the loss of hepatic vitamin A stores. To date, the molecular mechanisms and enzymes mediating the loss of hepatic vitamin A stores are incompletely understood. APPROACH AND

resultsUsing a fibrosis mouse model induced by the hepatotoxin carbon tetrachloride (CCl

conclusionTogether, these results indicate that the loss of hepatic retinyl ester stores upon liver injury and stellate cell activation is rather a consequence of reduced retinol esterification than neutral or acidic hydrolysis.

Indexed as

Chemical and Drug Induced Liver InjuryLiverLiver CirrhosisRetinoidsAcyltransferasesAnimalsCarbon TetrachlorideDisease Models, AnimalEsterificationHepatic Stellate CellsHydrolysisMaleMiceMice, Inbred C57BLVitamin AAcyltransferasesCarbon Tetrachloridelecithin-retinol acyltransferaseRetinoidsVitamin Afibrosislecithin:retinol acyltransferaseretinyl ester hydrolasesvitamin A

Identifiers

PMID40767555
PMCPMC12327178

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.