Evidence map›Paper›PMID 40767997›Full record

ArticleJournal of molecular histology2025

Salidroside alleviates cardiomyocyte senescence by activating the AMPK-mediated signaling pathway.

Lan Zhang, Yawei Liu, Zhijuan Hua, Yan Qin, Tao Wang, Na Li, Lei Song

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lan Zhang *Department of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, China.
Yawei Liu *Department of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, China.
Zhijuan HuaAffiliated Hospital of Hebei University, Baoding, China.
Yan QinExperimental Center of the Affiliated Hospital of Hebei University, Baoding, China.
Tao WangAffiliated Hospital of Hebei University, Baoding, China.
Na LiDepartment of Interventional Vascular Diseases, Affiliated Hospital of Hebei University, Baoding, China. zhanglan.syy@163.com.
Lei SongDepartment of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Hebei University, Baoding, China. songlei78630819@163.com.

Funding

the Cultivation Project of the Joint Fund for Traditional Chinese Medicine of the Natural Science Foundation of Hebei Province H2023201018
6 · The paper itself

Abstract

Cardiovascular aging is a key contributor to cardiovascular diseases (CVDs). As individuals age, the frequency and severity of cardiovascular events rise, establishing CVDs as a primary cause of death in older adults. Therefore, the development and exploration of drugs or bioactive molecules that can effectively prevent cardiovascular aging and related diseases are urgently needed. This study evaluated the effects of salidroside, a key component of Rhodiola rosea extract, on cardiomyocyte senescence. We established an in vitro cardiomyocyte senescence model using D-gal/H

Indexed as

AMP-Activated Protein KinasesCellular SenescenceGlucosidesMyocytes, CardiacPhenolsSignal TransductionAnimalsOxidative StressRatsRhodiolaAMP-Activated Protein KinasesGlucosidesPhenolsrhodiolosideAMPKCardiomyocytescGAS-STINGSalidrosideSenescence

Identifiers

PMID40767997

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.