Evidence map›Paper›PMID 40768004›Full record

ArticleIntensive care medicine experimental2025

Sodium thiosulfate does not affect energy metabolism or organ (dys)function during resuscitation from murine trauma-and-hemorrhage.

Maximilian Feth, Mirabel Gracco, Michael Gröger, Melanie Hogg, Sandra Kress, Andrea Hoffmann, Enrico Calzia, Ulrich Wachter, Peter Radermacher, Tamara Merz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maximilian FethDepartment of Anesthesiology, Critical Care, Emergency Medicine and Pain Therapy, German Armed Forces Hospital Ulm, Oberer Eselsberg 40, 89081, Ulm, Germany. maximilian.feth@uni-ulm.de.ORCID http://orcid.org/0000-0002-5428-3339
Mirabel GraccoInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Michael GrögerInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Melanie HoggInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Sandra KressInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Andrea HoffmannInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Enrico CalziaInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Ulrich WachterInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Peter RadermacherInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany.
Tamara MerzInstitute for Anesthesiological Pathohysiology and Process Engineering, Ulm University Hospital, Helmholtzstrasse 8/1, 89081, Ulm, Germany. tamara.merz@uni-ulm.de.

Funding

Deutsche Forschungsgemeinschaft 251293561Deutsche Forschungsgemeinschaft 278012962Deutsche Forschungsgemeinschaft 465409392
6 · The paper itself

Abstract

backgroundIn murine models, controversial data have been reported on the effect of hydrogen sulfide (H

methods30 mice underwent combined blast wave-induced blunt chest trauma followed by 1 h of hemorrhagic shock (mean arterial pressure MAP = 35 ± 5 mmHg). Thereafter, resuscitation was initiated comprising re-transfusion of shed blood, lung-protective mechanical ventilation, fluid resuscitation and continuous i.v. noradrenaline infusion to maintain MAP > 55 mmHg over 6 h, and randomized administration of either i.v. 0.45 mg/g

resultsData originate from 23 mice (Na DISCUSSION: In this model of resuscitated trauma-and-hemorrhage, Na

Indexed as

H2SMetabolismMitochondrial functionNitrosative stressOxidative stressStable isotopes

Identifiers

PMID40768004
PMCPMC12328856

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.