Evidence map›Paper›PMID 40768093›Full record

ArticleJournal of molecular modeling2025

Corona VRus Coaster: the virtual reality roller coaster of the proteins of SARS-CoV-2.

Alejandro Seco-González, César Porto, Ángel Piñeiro, Rebeca Garcia-Fandino

Abstract read
In one paragraph

Article in Journal of molecular modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alejandro Seco-GonzálezCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago, Spain.
César PortoCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago, Spain.
Ángel PiñeiroDepartamento de Física Aplicada, Facultade de Física, Universidade de Santiago de Compostela, Santiago, Spain. angel.pineiro@usc.es.
Rebeca Garcia-FandinoCentro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago, Spain. rebeca.garcia.fandino@usc.es.

Funding

Agencia Estatal de Investigación PID2019-111327GB-I00, PDC2022-133402-I00, PID2022-141534OB-I00, and CNS2023-144353Xunta de Galicia ED431C 2021/21 and Centro de Investigación do Sistema Universitario de Galicia accreditation 2023-2027, ED431G 2023/03
6 · The paper itself

Abstract

contextThe COVID-19 pandemic, caused by SARS-CoV-2, has driven significant research into the virus' structural components to elucidate its infection mechanisms and advance therapeutic strategies. However, the intricate architecture of viral proteins presents challenges for researchers and students in structural biology. To address this, we developed Corona VRus Coaster, a virtual reality (VR) application designed to facilitate molecular visualization. This tool enables immersive exploration of over 2000 viral proteins, including key structures such as the spike protein, nucleocapsid protein, main protease, and RNA-dependent RNA polymerase. Users can "ride" along the molecular backbones of these proteins, offering a distinctive way to explore their three-dimensional organization. Hand-tracking technology provides an intuitive interface for real-time interaction, while multiple visualization and navigation modes enhance the exploration experience. This application offers a novel and engaging approach to structural biology, supporting both research and education by making molecular structures more accessible and interactive. Corona VRus Coaster is available for download at http://mduse.com/coronavruscoaster .

methodsCorona VRus Coaster was developed using Unity3D and integrates molecular visualization frameworks such as the Molecular Rift toolkit for VR rendering. Protein structures were sourced from the Protein Data Bank (PDB) and converted into VR-compatible formats using Open Babel and PyMOL. The application employs hand-tracking technology via the Meta Interaction SDK to facilitate direct manipulation of molecular structures. The visualization modes incorporate different molecular representations, including ribbon, surface, and space-filling models, rendered using GPU-accelerated shaders. Navigation is enabled through VR motion controllers and gaze-based selection mechanisms. The modular software architecture allows seamless integration of newly resolved protein structures, ensuring flexibility for future molecular visualization applications.

Indexed as

SARS-CoV-2SoftwareViral ProteinsVirtual RealityCOVID-19HumansModels, MolecularProtein ConformationSpike Glycoprotein, CoronavirusSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral ProteinsImmersive technologyMolecular structuresProtein visualizationSARS-CoV-2Virtual reality

Identifiers

PMID40768093
PMCPMC12328519

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.