Evidence map›Paper›PMID 40768348›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant Na

Tong Wu, Xinyu Yang, Xueqin Jin, Nieng Yan, Zhangqiang Li

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A comprehensive study on freshwater pufferfishFrontiers in veterinary science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tong WuState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Xinyu YangState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Xueqin JinState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Nieng YanState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0003-4829-7416
Zhangqiang LiState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.ORCID 0000-0002-3296-2293

Funding

MOST | National Natural Science Foundation of China (NSFC) 32330052MOST | National Natural Science Foundation of China (NSFC) 32401004
6 · The paper itself

Abstract

The cardiac voltage-gated sodium channel Na

Indexed as

NAV1.5 Voltage-Gated Sodium ChannelTetrodotoxinCryoelectron MicroscopyHEK293 CellsHumansModels, MolecularNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanTetrodotoxincryo-EM structuresextracellular loops (ECLs)subtype specificityTTX-resistant and TTX-sensitiveβ subunits association

Identifiers

PMID40768348
PMCPMC12358880

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.