ReviewAging and disease2025
Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies.
Review in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Enhancing anti-fibrotic therapy: nanomedicine approaches to overcome current limitations.Materials today. Bio · 2026Review
- Age-stratified risk factors and predictive models for progression to lupus nephritis in patients with systemic lupus erythematosus: a review.Frontiers in immunology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence is one of the hallmarks of aging, and it is closely related to tissue fibrosis in various age-related diseases. By integrating multi-level and multi-dimensional data, emerging technologies can comprehensively analyze the complex mechanisms of aging and fibrosis diseases, discover new biomarkers and therapeutic targets, and promote the development of precision medicine. Most of the current reviews still focus on the molecular mechanisms of cellular senescence and fibrosis diseases, but lack a comprehensive summary of anti-aging drugs for the treatment of fibrosis-related diseases, and emerging technologies and integrated analysis of multi-omics data. This review discusses the latest evidence on the role of cellular senescence in tissue fibrosis, especially lungs, liver, and kidney fibrosis. In addition, we also introduce the application of anti-aging strategies in fibrotic diseases, especially drugs to eliminate senescent cells, and the latest application of emerging technologies in aging and fibrotic diseases.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.