Evidence map›Paper›PMID 40769720›Full record

ArticleGenes & development2025

MYOD represses gene expression from non-E-box motifs.

Chiara Nicoletti, Jimmy Massenet, Andreas P Pintado-Urbanc, Leah J Connor, Monica Nicolau, Swetha Sundar, Mingzhi Xu, Anthony Schmitt, Wenxin Zhang, Zesen Fang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Chiara Nicoletti *Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Jimmy Massenet *Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Andreas P Pintado-UrbancDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.ORCID 0000-0002-0649-9864
Leah J ConnorDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.
Monica NicolauDevelopment, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Swetha SundarDevelopment, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Mingzhi XuDevelopment, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Anthony SchmittArima Genomics, San Diego, California 92011, USA.
Wenxin ZhangDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Zesen FangDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Tsz Ching Indigo ChanDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Yu Xin WangDevelopment, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.ORCID 0000-0001-8440-9388
Stephen J TapscottHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.ORCID 0000-0002-0319-0968
Tom H CheungDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID 0000-0003-0796-5406
Matthew D SimonDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA.ORCID 0000-0001-7423-5265
Luca Caputo *Development, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA; lpuri@sbpdiscovery.org lcaputo@sbpdiscovery.org.ORCID 0000-0002-1697-9968
Pier Lorenzo PuriDevelopment, Aging, and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA; lpuri@sbpdiscovery.org lcaputo@sbpdiscovery.org.ORCID 0000-0003-4964-0095

Funding

Pathogenic Alterations of the 3D Epigenetic Landscape in Dystrophin-Deficient Skeletal Muscles and Reversal by Dystrophin Re-ExpressionR01AR056712 · NIAMS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Pier Lorenzo Puri · 2009 to 2026
$7.3M
Revealing the dynamics of RNA metabolism with nucleotide recoding chemistryR01GM137117 · NIGMS · YALE UNIVERSITY · PI Matthew David Simon · 2020 to 2026
$2.6M
NIAMS NIH HHS R01 AR056712NIGMS NIH HHS R01 GM137117
6 · The paper itself

Abstract

We report here on the identification of a previously unrecognized property of MYOD as a repressor of gene expression via E-box-independent chromatin binding during the process of somatic cell

Indexed as

E-Box ElementsGene Expression RegulationMyoD ProteinAnimalsCell DifferentiationCell LineCells, CulturedChromatinChromatin Assembly and DisassemblyFibroblastsHumansPromoter Regions, GeneticProtein BindingChromatinMyoD1 myogenic differentiation proteinMyoD Proteinchromatingene expressionMYOD

Identifiers

PMID40769720
PMCPMC12581818

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.