Evidence map›Paper›PMID 40770005›Full record

ArticleScientific reports2025

Explore the role of CBS in stomach adenocarcinoma based on the sulfur-containing amino acid metabolism network.

Ping Zhang, Yingchao Liu, Yajuan Lu, Aoli Deng, Jinghao Cao, Hangqi Huang, Cuiyun Wu, Jing Du, Yanchun Li, Jun Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ping Zhang *Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yingchao Liu *Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yajuan Lu *Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Aoli DengLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Jinghao CaoLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Hangqi HuangLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Cuiyun WuLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Jing DuLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. dujing1@hmc.edu.cn.
Yanchun LiDepartment of Clinical Laboratory, Affiliated Hangzhou First People's Hospital, School of Medical, Westlake University, Hangzhou, Zhejiang, China. lycmed@163.com.
Jun XiaLaboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. xiajun@hmc.edu.cn.

Funding

Basic Scientific Research Funds of Department of Education of Zhejiang Province No.KYYB2023012Medical and Health Science and Technology Project of Zhejiang Province No.2023RC228National Natural Science Foundation of China No.82202429Zhejiang Province Traditional Chinese Medicine Science and Technology Project No. 2022ZB018
6 · The paper itself

Abstract

The sulfur-containing amino acids (SAAs) play a key role in the occurrence and development of tumors. However, the clinical prognostic value of SAAs metabolism (SAAM) regulators in stomach adenocarcinoma (STAD) remains unclear. We systematically evaluated the clinical and immune characteristics of SAAM-related genes in STAD. Furthermore, a SAAM score model was constructed, and patients in the low-SAAM score group had a better prognosis. As the core gene in the model, the low expression of cystathionine beta-synthase (CBS) indicated a better prognosis for patients. Interfering with CBS expression in MKN-45 cells inhibited cell proliferation, reduced the production of glutathione (GSH), and promoted cellular oxidative stress. Importantly, the downregulation of CBS heightened sensitivity to ferroptosis inducers in STAD cells, highlighting the involvement of CBS in ferroptosis. In conclusion, the utilization of SAAM for the identification and personalized scoring of patients might potentially play a significant role in evaluating prognosis, immune infiltrates, and guiding treatment for STAD.

Indexed as

AdenocarcinomaAmino Acids, SulfurCystathionine beta-SynthaseStomach NeoplasmsCell Line, TumorCell ProliferationFemaleFerroptosisGene Expression Regulation, NeoplasticGlutathioneHumansMaleMetabolic Networks and PathwaysMiddle AgedOxidative StressPrognosisAmino Acids, SulfurCystathionine beta-SynthaseGlutathioneCystathionine beta-synthaseImmunotherapySAAM risk scoreStomach adenocarcinomaSulfur-containing amino acids

Identifiers

PMID40770005
PMCPMC12328571

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.