SynthesisTranslational psychiatry2025
Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.
Synthesis in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Isoorientin inhibits oxidative stress to ameliorate cognitive dysfunction in type 2 diabetes mice via GSK3β/Nrf2 axis.Metabolic brain disease · 2026Article
- Raphe subregion seeds reveal whole-brain functional connectivity differences underlying adolescent depression.BMC psychiatry · 2026Article
- Topological Property Impairments of Brain Functional Network in Newly-Onset Overweight/Obese Patients with Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Free water-mediated associations among choroid plexus enlargement, white matter lesions, and cognitive performance in type 2 diabetes mellitus.Frontiers in endocrinology · 2026Article
- Altered static and dynamic intrinsic brain activity patterns in type 2 diabetic patients.Scientific reports · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundType 2 diabetes mellitus (T2DM) is a prevalent chronic condition associated with a range of abnormalities in both the functional and structural aspects of the brain. However, existing studies have produced inconsistent results due to disease heterogeneity and small sample size. Therefore, we aim to examine common functional and structural alterations in patients with T2DM.
methodWe searched PubMed, Web of Science, and Embase (published before July 2023) and included a total of 52 valid studies (58 datasets), which have 2160 patients with T2DM and 2124 healthy controls (HCs). Then, we used the anisotropic effect size seed-based d mapping (AES-SDM) to examine changes in neural activity and grey matter volume (GMV) in patients with T2DM. To validate the findings of the AES-SDM results, two additional meta-analyses were performed using activation likelihood estimation (ALE) and multilevel kernel density analysis (MKDA).
resultsThe results showed that patients with T2DM exhibited abnormal neural activity, functional connectivity of default mode network, and GMV in brain regions related to visual processing, such as the occipital lobe, lingual gyrus, and Heschl's gyrus. In addition, functional or structural alterations were also found in other sensory-motor, cognitive, and attention-related brain regions in patients with T2DM. The results of ALE and MKDA fundamentally confirmed the findings of the AES-SDM analysis.
conclusionThese findings offer robust neural markers and deepen our understanding of the neurobiological underpinnings of T2DM.
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