Evidence map›Paper›PMID 40770531›Full record

Trial reportGeroScience2025

Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial.

Yi Lin, Rola S Zeidan, Stephanie Lapierre-Nguyen, Hannah M Costello, Stephen D Anton, Thomas W Buford, Demetra D Christou, Michelle L Gumz, Christiaan Leeuwenburgh, Christopher R Martens and 7 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yi Lin *Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Rola S Zeidan *Department of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Stephanie Lapierre-NguyenUniversity of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hannah M CostelloDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Stephen D AntonDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Thomas W BufordDivision of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Demetra D ChristouDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Michelle L GumzDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Christiaan LeeuwenburghDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Christopher R MartensDepartment of Kinesiology and Applied Physiology, University of Delaware, Delaware, DE, USA.
Mary M McDermottDepartment of Internal Medicine, Northwestern University, Chicago, IL, USA.
Marie E MigaudDepartment of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Bhanuprasad SandesaraDepartment of Medicine, Division of Geriatric Medicine, University of Florida, Gainesville, FL, USA.
Douglas R SealsDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Peihua QiuDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Yipeng WangDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Robert T MankowskiDivision of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. rmankowski@uabmc.edu.

Funding

UAB Nutrition Obesity Research Center (NORC)P30DK056336 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2000 to 2025
$6.0M
Validation of NAD+ measurements for human clinical studies: multi-method inter-laboratory standardizationU01AG089107 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$939k
Translational Research Training on Aging and Mobility (TRAM)T32AG062728 · UNIVERSITY OF FLORIDA · 2025 to 2025
$351k
NIA NIH HHS R21 AG064282NIA NIH HHS R21AG064282NIA NIH HHS T32 AG062728NIA NIH HHS T32AG062728NIA NIH HHS U01 AG089107NIA NIH HHS U01AG089107NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

Aerobic exercise lowers blood pressure (BP) with varying effects in hypertensive adults, potentially due to age-related nicotinamide adenine dinucleotide (NAD) metabolism dysregulation. This pilot randomized clinical trial (RCT) tested the efficacy of combining aerobic exercise with the NAD booster nicotinamide riboside (NR) to enhance BP control. In this double-blinded RCT, 54 sedentary adults (≥ 55 years) with mean daytime systolic BP (SBP) ≥ 130 mmHg were randomized to 6 weeks of 1000 mg/day of NR combined with 3 days/week of supervised 30-min walking exercise (NR + Ex), Placebo combined with the same exercise regimen (PL + Ex), or NR alone (NR). The primary outcome was daytime SBP. Other outcomes included pulse wave velocity (PWV), NAD catabolites, and nighttime BP. The primary comparison was between NR + Ex and PL + Ex. Of 54 participants (mean age 67 years, 61% female), 49 (NR + Ex: n = 15, PL + Ex: n = 16, NR: n = 18) completed all study visits (93% adherence to exercise and 90% to supplementation). NR + Ex (mean change = 5.19 ± 13.2 mmHg) did not reduce SBP more than PL + Ex (- 2.71 ± 10.5 mmHg). NR + Ex (- 0.31 ± 0.77 m/s) showed a trend toward a greater reduction in PWV. Levels of NAD catabolites were higher in NR groups. In a post hoc analysis, NR + Ex showed a trend toward greater nighttime BP reductions (systolic: - 9.6 ± 9.22; diastolic: - 4.51 ± 7.12 mmHg) in participants without antihypertensive medications. NR + Ex was not superior to PL + Ex in reducing BP in hypertensive middle-aged and older. However, trends toward greater nighttime BP reduction in NR + Ex in participants without antihypertensive medication warrant further investigation in a Phase IIb RCT.

Indexed as

ExerciseExercise TherapyHypertensionNiacinamideAgedBlood PressureDouble-Blind MethodFemaleHumansMaleMiddle AgedPilot ProjectsPulse Wave AnalysisPyridinium CompoundsTreatment OutcomeNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsExerciseHypertensionNicotinamide ribosideOlder adults

Identifiers

PMID40770531
PMCPMC12638573

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.