ArticleBMC pregnancy and childbirth2025
Trends and regional disparities in maternal hypertensive disorders among women of childbearing age: a global burden of disease analysis from 1990 to 2021.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The association between air pollution and hypertension: An umbrella review of systematic reviews and meta-analyses.iScience · 2026Article
- Article
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7 authors.
Funding
Abstract
backgroundMaternal hypertensive Disorders (MHD), including gestational hypertension, preeclampsia, and eclampsia, remain a major contributor to maternal and neonatal morbidity and mortality worldwide. While global healthcare advancements have improved maternal survival, the incidence of MHD continues to rise, particularly in low- and middle-income countries (LMICs).
objectiveThis study aimed to comprehensively assess the global and regional trends in the burden of MHD among women aged 15–49 years from 1990 to 2021 using data from the Global Burden of Disease (GBD) 2021 study. We examined disparities across countries and Socio-Demographic Index (SDI) regions, analyzed the influence of demographic and epidemiological factors through decomposition analysis, and projected future trends in MHD burden through 2050 using a Bayesian age-period-cohort (BAPC) model.
methodsWe extracted incidence, mortality, and disability-adjusted life years (DALYs) of women aged 15–49 years from the GBD 2021 database across 204 countries. Temporal trends were analyzed using Joinpoint regression and the estimated annual percentage change (EAPC). Socioeconomic disparities were evaluated using the SDI, and future projections were conducted using a BAPC model with sensitivity analysis.
resultsThe global MHD mortality (AAPC: -2.16%; 95% CI: -2.1 to -2.21) and incidence (AAPC: -0.5%, 95% CI: -0.45% to -0.56%) rate has declined. Decomposition analysis revealed that population growth and epidemiological changes were the main drivers of the increasing incidence, while aging had a less pronounced effect. Health inequality analysis demonstrated a clear negative correlation between MHD burden and socioeconomic development, highlighting the disproportionate impact on disadvantaged populations.
conclusionThe global burden of MHD exhibits significant regional disparities, with an declined trend in incidence. To address this persistent challenge, targeted interventions focusing on strengthening healthcare systems, improving access to quality obstetric care, and addressing socioeconomic inequities are urgently needed.
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