ArticleDiabetology & metabolic syndrome2025
Effect of intermittent fasting, portfolio-moderate-carbohydrate, and anti-inflammatory diets on cardio-metabolic status in pre-diabetic patients; an open-label randomized clinical trial.
Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of intermittent fasting on blood glucose and weight in type 2 diabetes and prediabetes: A comparison with ad libitum and continuous energy restriction diets.Asia Pacific journal of clinical nutrition · 2026Pooled it
- Intermittent fasting to treat diabetes: time to update clinical practice guidelines.The lancet. Diabetes & endocrinology · 2026Review
- Correction: Effect of intermittent fasting, portfolio-moderate-carbohydrate, and anti-inflammatory diets on cardio-metabolic status in pre-diabetic patients; an open-label randomized clinical trial.Diabetology & metabolic syndrome · 2026Article
- Evaluation of nutritional interventions and their impact on metabolic syndrome risk markers in older adults.Frontiers in nutrition · 2026Article
- Anti-inflammatory diets for prediabetes remission: a mechanistic and practical roadmap.Frontiers in immunology · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
backgroundPre-diabetes is a condition characterized by hyperglycemia that does not meet the cutoff for the diagnosis of diabetes and increases the risk of non-communicable diseases. Choosing an appropriate diet is necessary to prevent the progression of pre-diabetes to diabetes. Therefore, the present study aimed to compare the effects of 3 diets, including intermittent fasting (IF) 5:2, portfolio-moderate-carbohydrate (PMC), and anti-inflammatory (AI) diets, compared to a healthy diet with carbohydrate distribution.
methodsThis open label randomized clinical trial was performed on 98 patients with pre-diabetes that were randomly divided into four intervention groups, including IF 5:2 (n = 24), PMC (n = 24), AI (n = 25), and control group (n = 25). Adherence to these dietary intervention was assessed by dietary recall. Glycemic indices (fasting blood sugar (FBS) and hemoglobin A1c (HbA1c)), lipid profile, body composition, anthropometric indices (weight, waist circumference (WC), and body mass index (BMI)), and hs-C reactive protein (CRP) were assessed before and after dietary intervention. Mixed model regression was used for statistical analysis.
resultsCompared to the control group, the AI diet significantly reduced weight (β: -1.02; 95% CI: -1.96, -0.07; P = 0.017), FBS (β: -6.42; 95% CI: -12.9, -0.06; P = 0.026), and HbA1c (β: -0.27; 95% CI: -0.55, -0.007; P = 0.028). IF 5:2 showed significant reductions in waist circumference, BMI, FBS, and HbA1c, while PMC intervention resulted in significant improvements in FBS and HbA1c compared to the control group.
conclusionsThe study demonstrated that AI, IF 5:2, and PMC diets improved glycemic control and anthropometric indices in pre-diabetic patients, with the AI diet showing the greatest beneficial effects. These findings suggest that anti-inflammatory dietary approaches may be an effective strategy for pre-diabetes management. LEVEL OF EVIDENCE: Level I, randomized clinical trial.
trial registrationRegistration number IRCT20200608047697N2, data 2024-05-16, https://irct.behdasht.gov.ir/trial/76653 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.