ReviewClinical epigenetics2025
Lactylation modifications in urological diseases: molecular mechanisms and biological implications.
Review in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Interplay between N6-methyladenosine RNA methylation and protein lactylation: a novel crosstalk linking metabolism and epigenetic regulation in human diseases.Journal of translational medicine · 2026Review
- Inhibiting lactylation for efficient treatment of renal fibrosis through targeting nanomedicine of renal lactate accumulation in obstructed kidney.Journal of nanobiotechnology · 2026Article
- Lactylation: a metabolic-epigenetic bridge in diabetic kidney disease and a therapeutic target for TCM.Chinese medicine · 2026Review
- Role of metabolic reprogramming and lactylation in diabetic nephropathy: molecular mechanisms and therapeutic prospects - a narrative review.Frontiers in endocrinology · 2026Review
- Genetic depletion or pharmacological degradation of EZH2 attenuates renal fibrosis via suppressing Notch signaling.Clinical epigenetics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Urological disorders encompass a broad spectrum of medical conditions that affect the kidneys, ureters, bladder, and urethra. Among these, urinary tract infections, kidney stones, renal dysfunction, and urological malignancies are commonly observed, each exhibiting distinct pathophysiological mechanisms. Due to their diverse etiologies and heterogeneous nature, strategies for prevention and treatment must be tailored to the specific characteristics of each disease. Lactylation, a recently recognized post-translational modification, arises from excessive lactate accumulation. This biochemical alteration occurs in histones, where it influences gene transcription, and in non-histone proteins, where it modulates their functional properties. Recent research indicates that lactylation significantly contributes to the development of various urological diseases by affecting key biological processes such as inflammation, angiogenesis, lipid metabolism, and fibrosis. Given its involvement in these pathological pathways, precise regulation of lactylation presents a promising avenue for both prognostic evaluation and therapeutic intervention in urological disorders. This review offers a thorough examination of lactylation, exploring its biological functions and mechanistic roles in urological diseases. In particular, it underscores the impact of lactylation on disease initiation and progression while providing novel insights into its therapeutic and preventive potential. By clarifying the role of lactylation in urological pathology, this analysis aims to support future scientific inquiries and clinical advancements in this expanding field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.