Evidence map›Paper›PMID 40770818›Full record

ArticleStem cell research & therapy2025

Emodin-Enhanced hUC-MSC extracellular vesicles alleviate acute pancreatitis by targeting inflammation and pyroptosis.

Xiong Liu, Xianwei Huang, Xiaodong Huang, Siyao Liu, Jun Hu, Jiyan Lin

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Xiong Liu *Department of Emergency, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Xianwei Huang *Department of Emergency, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China. hxw20126@xmu.edu.cn.
Xiaodong HuangDepartment of Emergency, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Siyao LiuDepartment of Emergency, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Jun HuDepartment of Emergency, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China.
Jiyan LinDepartment of Emergency, School of Medicine, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen, China. linjiy@xmu.edu.cn.

Funding

Natural Science Foundation of Fujian Province 2024J011359Natural Science Foundation of Xiamen 3502Z202374002
6 · The paper itself

Abstract

backgroundAcute pancreatitis (AP) is a complex condition requiring immediate treatment. Both extracellular vesicles derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EVs) and emodin, a naturally occurring anthraquinone used in traditional Chinese medicine, have shown therapeutic potential in treating AP. However, the mechanisms by which hUC-MSC-EVs and emodin alleviate AP, and whether they exert a synergistic effect on inflamed pancreatic tissues, remain unclear.

objectiveOur study aimed to evaluate the efficacy of emodin, hUC-MSC-EVs, and their combination in AP, explore synergistic mechanisms, and propose hUC-MSC-EVs as a novel drug delivery strategy for therapeutic applications.

designIn this study, we developed AP cell, organoid, and animal models to compare the effects of emodin, hUC-MSC-EVs, and emodin-loaded hUC-MSC-EVs on cell viability, inflammation, and pyroptosis.

resultsOur data revealed that all three treatments improved cell viability, reduced pro-inflammatory cytokine expression, and inhibited pyroptosis in the AP models. Notably, the encapsulation of emodin significantly enhanced the protective effects of hUC-MSC-EVs.These findings suggest that emodin's protective effects on inflamed pancreatic tissues may be attributed, at least in part, to its anti-inflammatory and anti-pyroptotic properties. Additionally, our study proposes a novel strategy for engineering hUC-MSC-EVs for potential therapeutic applications in AP treatment.

Indexed as

EmodinExtracellular VesiclesInflammationMesenchymal Stem CellsPancreatitisPyroptosisAnimalsCell SurvivalDisease Models, AnimalHumansMaleMiceUmbilical CordEmodinAcute pancreatitisAR42J cellsEmodinExtracellular vesicleHuman umbilical cord mesenchymal stem cells (hUC-MSCs)Pyroptosis

Identifiers

PMID40770818
PMCPMC12330194

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.