ArticleThe International journal of angiology : official publication of the International College of Angiology, Inc2025
Temporal Trends in Pulmonary Embolism Mortality Associated with COVID-19 in the United States: A 5-Year Retrospective Analysis.
Article in The International journal of angiology : official publication of the International College of Angiology, Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Coronavirus disease 2019 (COVID-19) has been strongly associated with thrombotic complications, particularly pulmonary embolism (PE). This study aims to analyze the real-world impact of COVID-19 on PE-related mortality in the United States over the first 5 years of the pandemic. We conducted a retrospective observational study using the CDC WONDER database, combining data on mortality from PE and COVID-19 using the 10th revision of the International Classification of Diseases (ICD-10) codes I26 (PE) and U07.1 (COVID-19). The analysis spanned from 2020 to 2024. We found a peak in COVID-19-associated PE deaths in 2021, with an estimated crude rate of 211 × 1,000 PE deaths. This rate progressively declined over the following years, being 141 × 1,000 in 2022, 44 × 1,000 in 2023, and 29 × 1,000 in 2024, respectively. The estimated crude rate for COVID-19-associated PE in the United States was 111 × 1,000 PE deaths throughout the 5-year period. The results of our study show that COVID-19 may have contributed to nearly one-tenth of all PE deaths throughout the first 5 years of the pandemic. Despite the gradual decline over the years since its peak in 2021, the still sustained mortality suggests ongoing thrombotic risks, especially impacting high-risk populations, emphasizing the need for continued vigilance and prevention of thrombotic complications in COVID-19 patients.
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