Evidence map›Paper›PMID 40771477›Full record

ReviewFrontiers in medicine2025

Advances in ocular aging: combining deep learning, imaging, and liquid biopsy biomarkers.

Dengren Zhang, Naiyang Li, Fan Li

Abstract readReview
In one paragraph

Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dengren ZhangEye Center, Zhongshan City People's Hospital, Zhongshan, China.
Naiyang LiEye Center, Zhongshan City People's Hospital, Zhongshan, China.
Fan LiEye Center, Zhongshan City People's Hospital, Zhongshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ageing is a significant risk factor for a wide range of human diseases. Yet, its direct relationship with ocular ageing as a marker for overall age-related diseases and mortality still needs to be explored. Non-invasive and minimally invasive methods, including biomarkers detected through ocular imaging or liquid biopsies from the aqueous humour or vitreous body, provide a promising avenue for assessing ocular ageing. These approaches are particularly valuable given the eye's limited regenerative capacity, where tissue damage can result in irreversible harm. In recent years, artificial intelligence (AI), particularly deep learning, has revolutionized medical research, offering novel perspectives on the ageing process. This review highlights how integrating deep learning with advanced imaging and liquid biopsy biomarkers has become a transformative approach to understanding ocular ageing and its implications for systemic health.

Indexed as

age-related eye diseasesdeep learningimagingliquid biopsyocular aging

Identifiers

PMID40771477
PMCPMC12325013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.