Evidence map›Paper›PMID 40772316›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Hydrogen Sulfide Protects Erectile Function Through Stimulation of Antioxidant Defense in the Corpus Cavernosum: Insights From SG1002 Administration and Cystathionine γ-Lyase Knockout.

Tooyib A Azeez, Paige R Rhein, Clifford J Pierre, Colin M Ihrig, Justin D La Favor

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Cystathionine γ lyase deletion enhances corpus cavernosum contraction via thromboxane AAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Tooyib A AzeezDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, USA.ORCID https://orcid.org/0000-0002-8101-2112
Paige R RheinDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, USA.ORCID https://orcid.org/0009-0002-3701-7132
Clifford J PierreDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, USA.ORCID https://orcid.org/0000-0002-9992-657X
Colin M IhrigDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, USA.ORCID https://orcid.org/0009-0000-5373-6490
Justin D La FavorDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, USA.ORCID https://orcid.org/0000-0002-0845-3421

Funding

Role of Hydrogen Sulfide Depletion in Western Diet-Induced Erectile DysfunctionK01DK115540 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LAFAVOR, JUSTIN DAVID · 2017 to 2021
$842k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K01DK115540NIDDK NIH HHS K01 DK115540Sexual Medicine Society of North America (SMSNA)
6 · The paper itself

Abstract

Obesity is a major risk factor for erectile dysfunction, whereby excess reactive oxygen species (ROS) in the corpus cavernosum have been implicated as a causative factor. Hydrogen sulfide (H

Indexed as

AntioxidantsCystathionine gamma-LyaseErectile DysfunctionHydrogen SulfidePenile ErectionPenisAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutReactive Oxygen SpeciesAntioxidantsCystathionine gamma-LyaseHydrogen SulfideReactive Oxygen SpeciesCSEcystathionine gamma‐lyaseerectile dysfunctionmicrodialysisobesityoxidative stressROSSG1002western diet

Identifiers

PMID40772316
PMCPMC12329644

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.