Evidence map›Paper›PMID 40773151›Full record

Trial reportJournal of neuro-oncology2025

Social support moderates quality of life outcomes during a mind-body intervention among adults with neurofibromatosis.

Julie R Brewer, Julia E Hooker, Millan Kanaya, Danielle E LaCamera, Jafar Bakhshaie, Ana-Maria Vranceanu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03406208 (Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03406208 nacompletednot on this map

Resiliency Training for Adults With Neurofibromatosis Via Live Videoconferencing

TypeinterventionalSponsorMassachusetts General HospitalRan2017 to 2022Enrolled228ConditionsNeurofibromatoses, Neurofibromatosis 1, Neurofibromatosis 2, SchwannomatosisArmsStress and Symptom Management Program 1, Stress and Symptom Management Program 2
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julie R BrewerDepartment of Psychology, George Mason University, Fairfax, VA, 22030, USA.ORCID http://orcid.org/0000-0001-5581-2434
Julia E HookerCenter for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0001-9890-7572
Millan KanayaDepartment of Psychology, University of Miami, Coral Gables, 33146, USA.ORCID http://orcid.org/0000-0003-1538-8012
Danielle E LaCameraCenter for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID http://orcid.org/0009-0002-6563-4074
Jafar BakhshaieCenter for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0002-5906-1292
Ana-Maria VranceanuCenter for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, Boston, MA, 02114, USA. avranceanu@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-3994-6488

Funding

U.S. Department of Defense W81XWH-17-1-0121
6 · The paper itself

Abstract

purposeNeurofibromatoses (NF; NF1, NF2-related schwannomatosis, and other forms) are incurable genetic disorders linked to poor quality of life (QoL). Limited research exists on social support as a protective factor for QoL in NF. This secondary analysis examined whether baseline social support moderates QoL outcomes in individuals with NF.

methodsParticipants (N = 228, M

resultsIndividuals with higher baseline social support reported consistently higher QoL across both interventions, achieving clinically meaningful improvement, while those with low social support did not. No significant 3-way interactions were found between time, social support, and group from baseline to post-test (ps = 0.13-0.83) or follow-up (ps = 0.21-0.69). However, exploratory analyses showed a significant interaction between time and baseline social support for the 3RP-NF group in social, environmental, and psychological QoL at post-test (ps = 0.02-0.05), with a sustained effect at follow-up for social QoL (p = .01). No such effects were found in the HEP-NF group (ps = 0.25-0.68).

conclusionIn adults with NF, baseline social support moderates social and environmental QoL in mind-body interventions. Enhancing social support early may particularly benefit individuals with initially low support, though further research is needed to identify effective strategies for achieving clinically meaningful changes.

trial registrationClinicalTrials.gov Identifier NCT03406208. https://clinicaltrials.gov/study/NCT03406208.

Indexed as

Mind-Body TherapiesNeurofibromatosesQuality of LifeSocial SupportAdultFemaleFollow-Up StudiesHumansMaleMiddle AgedYoung AdultChronic conditionNeurofibromatosisQuality of lifeResilienceSocial support

Identifiers

PMID40773151

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.