Evidence map›Paper›PMID 40773880›Full record

ArticleJournal of colloid and interface science2025

Janus acoustically responsive scaffolds for sequential drug release with phase-programmed steady and pulsatile kinetics.

Haijun Xiao, Somnath Maji, Abigail Pinch, Mitra Aliabouzar, Mario L Fabiilli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of colloid and interface science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haijun XiaoDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA.
Somnath MajiDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA.
Abigail PinchDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, MI, USA.
Mitra AliabouzarDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, 48109, MI, USA.
Mario L FabiilliDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, MI, USA; Applied Physics Program, University of Michigan, Ann Arbor, 48109, MI, USA. Electronic address: mfabiill@umich.edu.

Funding

Angiogenic growth factor delivery for vascular regeneration in critical limb ischemia using acoustically-responsive scaffoldsR01HL139656 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mario Leonardo Fabiilli · 2018 to 2026
$5.7M
NHLBI NIH HHS R01 HL139656
6 · The paper itself

Abstract

Achieving precise temporal control over drug release kinetics, including sequential delivery with varied profiles, is crucial for optimizing therapeutic outcomes. However, engineering systems capable of sequential release combining distinct kinetics (e.g., steady and pulsatile) remains challenging. Here we developed a novel Janus acoustically responsive scaffold (ARS) for achieving precisely controlled sequential drug release using ultrasound. The Janus ARS is a composite hydrogel containing fibrin and different phase-shift emulsions within each half. Upon exposure to ultrasound, drug release is triggered by acoustic droplet vaporization (ADV), which induces bubble formation within the dispersed, liquid perfluorocarbon phase of each emulsion. We characterized release kinetics and morphological changes in ARSs with emulsions containing perfluorohexane or perfluorooctane. ARSs with perfluorohexane emulsion exhibited a triphasic release profile with bubbles retained in the fibrin hydrogel and steady release occurring over days. Contrastingly, ARSs with perfluorooctane emulsion exhibited a biphasic profile with macropore formation and pulsatile release following ultrasound exposure. Sequential release of two payloads was successfully achieved by leveraging the distinct properties of the two emulsion types and their frequency-dependent ADV behavior. In addition, quantitative models describing release from both sides of the Janus ARS were developed and validated. These results demonstrate the potential of Janus ARSs to provide advanced drug delivery solutions for complex therapeutic challenges currently unmet by conventional single-profile controlled release systems, offering a versatile platform for sophisticated temporal drug presentation.

Indexed as

AcousticsDrug Delivery SystemsFluorocarbonsHydrogelsDrug LiberationEmulsionsFibrinKineticsParticle SizeEmulsionsFibrinFluorocarbonsHydrogelsperflexaneAcoustic droplet vaporizationFibrin hydrogelKineticsPerfluorocarbonPulsatile releaseSequential releaseUltrasoundZero order release

Identifiers

PMID40773880
PMCPMC12557305

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.