Observational studyJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2025
Prospective Analysis of Mesotheliomas in Subjects With BAP1 Cancer Syndrome: Clinical Characteristics and Epigenetic Correlates of Disease.
Observational study in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04431024 (Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome
Who cites it
4 citing papers in PubMed.
- Distinct epidemiologic patterns of mesothelioma: evidence from a 16-year provincial cohort in China.BMC cancer · 2026Article
- Review
- Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Review
- Advances in diagnosis and management of pleural mesothelioma: the Danish clinical guidelines.European clinical respiratory journal · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Funding
Abstract
introductionAlthough mesotheliomas are the most common malignancies identified in BAP1 cancer syndrome (BCS), the prevalence and natural history of the neoplasms have not been elucidated. Protocol NCT04431024 was initiated to prospectively evaluate whether high-resolution computed tomography (CT) imaging and minimally invasive surgical evaluation could facilitate detection and surveillance of mesotheliomas in subjects with germline BAP1 mutations.
methodsSubjects above or equal to 33 years of age with or without prior malignancies underwent CT imaging followed by bilateral thoracoscopies and laparoscopies. CT imaging and intraoperative findings were objectively scored; surgical biopsies were interpreted by two expert pathologists. Skin, peripheral blood mononuclear cells, plasma, serum, and tumor biopsies were collected for correlative research studies.
resultsA total of 50 subjects with 32 germline BAP1 mutations were enrolled between March 2021 and July 2024. Median follow-up was 21.8 months (range: 1.7-41.1 mo). Furthermore, 16 sites of prior mesothelioma in 15 patients were excluded from the analysis. Surgical evaluation identified diffuse mesotheliomas in 39 of 45 subjects (87%), affecting 63 of 81 hemi-thoraces (78%) and 27 of 32 peritoneal cavities (84%); these mesotheliomas exhibited unique histologic features and slow clinical progression without therapeutic interventions. CT scans were unreliable for detecting or ruling out these mesotheliomas. Common and mutation specific, cancer-associated epigenomic alterations were identified in dermal fibroblasts and peripheral blood mononuclear cells, which correlated with cancer predilection in subjects with BCS.
conclusionsAdult subjects with germline BAP1 mutations exhibit a high prevalence of subclinical, multicompartment mesotheliomas, which may be manifestations of systemic epigenetic burdens. These findings establish a paradigm for longitudinal assessment of subjects with BCS and support further efforts to identify and validate epigenetic biomarkers for the detection and surveillance of mesotheliomas and other malignancies arising in these individuals.
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Registered trials
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